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(±)17-HETE

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(±)17-HETE Basic information

Product Name:
(±)17-HETE
Synonyms:
  • (±)17-HETE
  • OPPIPPRXLIDJKN-JPURVOHMSA-N
  • 5,8,11,14-Eicosatetraenoic acid, 17-hydroxy-, (5Z,8Z,11Z,14Z)-
  • 17-hydroxy-5(Z),8(Z),11(Z),14(Z)-eicosatetraenoic acid
CAS:
128914-47-6
MF:
C20H32O3
MW:
320.47
Mol File:
128914-47-6.mol
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(±)17-HETE Chemical Properties

storage temp. 
Store at -20°C
solubility 
0.1 m Na2CO3: 2 mg/ml; DMF: Miscible; DMSO: Miscible; Ethanol: Miscible; PBS (pH 7.2): 0.8 mg/ml
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(±)17-HETE Usage And Synthesis

Description

Electrolyte and fluid transport in the kidney are regulated in part by arachidonic acid and its metabolites. (±)17-HETE is the racemic version of a cytochrome P450 (CYP450) metabolite of arachidonic acid that has stereospecific effects on sodium transport in the kidney. At a concentration of 2 μM the (S)-enantiomer of 17-HETE inhibits proximal tubule ATPase activity by as much as 70%, whereas the (R)-isomer is inactive.

Definition

ChEBI: A HETE that consists of arachidonic acid bearing an additional hydroxy substituent at position 17.

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