bortezoMib iMpurity H Chemical Properties

solubility 

Chloroform (Slightly), Dichloromethane (Slightly)

form 

Solid

color 

White to Off-White

InChI

InChI=1S/C19H24N4O2/c1-14(2)8-9-22-18(24)16(12-15-6-4-3-5-7-15)23-19(25)17-13-20-10-11-21-17/h3-7,10-11,13-14,16H,8-9,12H2,1-2H3,(H,22,24)(H,23,25)/t16-/m0/s1

InChIKey

UJZOAWFAGJVEGQ-INIZCTEOSA-N

SMILES

C1(C(N[C@@H](CC2=CC=CC=C2)C(NCCC(C)C)=O)=O)=NC=CN=C1

bortezoMib iMpurity H Usage And Synthesis

Uses

N-[(1S)-2-[(3-Methylbutyl)amino]-2-oxo-1-(phenylmethyl)ethyl]-2-pyrazinecarboxamide is an impurity of Bortezomib (B675700) which is the first proteasome inhibitor to be approved by the US FDA for multiple myeloma, a blood cancer. A reversible inhibitor of the 26S proteasome-a barrel-shaped multiprotein particle found in the nucleus and cytosol of all eukaryotic cells. Targets the ubiquitin-proteasome pathway.

bortezoMib iMpurity H(1446194-56-4)Related Product Information

• Bortezomib
• (S)-N-(1-AMino-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxaMide