ChemicalBook > Product Catalog > Biochemical Engineering > Inhibitors > Apoptosis > Mdm2 inhibitors > RG-7388
RG-7388
RG-7388 Basic information
- Product Name:
- RG-7388
- Synonyms:
-
- Idasanutlin
- 4-[[[(2R,3S,4R,5S)-3-(3-Chloro-2-fluorophenyl)-4-(4-chloro-2-fluorophenyl)-4-cyano-5-(2,2-dimethylpropyl)-2-pyrrolidinyl]carbonyl]amino]-3-methoxybenzoic acid
- RG 7388
- RG7388
- RG-7388
- RG-7388, Idasanutlin
- Idasanutlin (RG-7388)
- RG 7388; RG-7388; RG7388
- CAS:
- 1229705-06-9
- MF:
- C31H29Cl2F2N3O4
- MW:
- 616.48
- Product Categories:
-
- Inhibitors
- Mol File:
- 1229705-06-9.mol
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RG-7388 Chemical Properties
- Melting point:
- >261° (dec.)
- Boiling point:
- 737.3±60.0 °C(Predicted)
- Density
- 1.40±0.1 g/cm3(Predicted)
- storage temp.
- -20°C Freezer
- solubility
- DMSO (Slightly), Methanol (Slightly)
- pka
- 4.11±0.10(Predicted)
- form
- Solid
- color
- White to Off-White
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RG-7388 Usage And Synthesis
Description
Potent MDM2 inhibitor with an IC50 = 6 nM in binding assay and 30 nM in cancer cell proliferation assay. Induces p53 stabilisation, cell cycle arrest and apoptosis in cancer cells expression wildtype p53. Displays inhibition of tumor growth in the SJSA1 tumor xenograft model. Also inhibits MDR-1 at high concentrations.
Uses
Idasanutlin is an MDM2 inihibtor, blocking the p53 protein-protein interaction and may be used in anti-cancer treatments.
storage
Store at -20°C
RG-7388Supplier
Changzhou Chenhong Biotechnology Co., Ltd. Gold
- Tel
- 0519-85788828 13775037613
- sales@chemrenpharm.com
Shanghai Chaolan Chemical Technology Center Gold
- Tel
- QQ:65489617 15618227136
- info@SuperLan-chem.com
Shanghai Boyle Chemical Co., Ltd.
- Tel
- sales@boylechem.com
BeiJing Hwrk Chemicals Limted
- Tel
- 0757-86329057 18934348241
- sales4.gd@hwrkchemical.com
Tongchuang Pharma(Suzhou). Co., Ltd.
- Tel
- 0512-63263366 18912765016
- tongtf110@sina.com