SBE13 Chemical Properties

Boiling point:

582.8±45.0 °C(Predicted)

Density 

1.196±0.06 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

Soluble in DMSO

pka

8.67±0.19(Predicted)

form 

solid

color 

beige

SBE13 Usage And Synthesis

Uses

SBE13 is a potent and selective Plk1 inhibitor, with an IC50 of 200 pM; SBE13 poorly inhibits Plk2 (IC50>66?μM) or Plk3 (IC50=875?nM).

IC 50

PLK1: 200 pM (IC₅₀); PLK3: 875 nM (IC₅₀)

References

[1] Keppner S, et al. Identification and validation of a potent type II inhibitor of inactive polo-like kinase 1. ChemMedChem. 2009 Nov;4(11):1806-9. DOI:10.1002/cmdc.200900338
[2] Keppner S, et al. Fate of primary cells at the G?/S boundary after polo-like kinase 1 inhibition by SBE13. Cell Cycle. 2011 Feb 15;10(4):708-20. Epub 2011 Feb 15. DOI:10.4161/cc.10.4.14898
[3] Keppner S, et al. Biological impact of freezing Plk1 in its inactive conformation in cancer cells. Cell Cycle. 2010 Feb 15;9(4):761-73. Epub 2010 Feb 16. DOI:10.4161/cc.9.4.10644

SBE13(775294-82-1)Related Product Information

• SBE 13 hydrochloride