TN ANTIGEN
TN ANTIGEN Basic information
- Product Name:
- TN ANTIGEN
- Synonyms:
-
- GALNAC-ALPHA1-O-SER
- SERINYL 2-ACETAMIDO-2-DEOXY-A-GALACTOPYRANOSIDE
- Ser(α-D-GalNHAc)-OH
- N-ACETYLGALACTOSAMINE, ALPHA1-O-SERINE
- N-ACETYL-ALPHA-D-GALACTOSAMINYL-1-O-SERINE
- TN EPITOPE
- TN ANTIGEN
- Serinyl 2-acetamido-2-deoxy-a-galactopyranoside, N-acetyl-a-D-galactosaminyl-1-O-serine
- CAS:
- 67262-86-6
- MF:
- C11H20N2O8
- MW:
- 308.29
- Product Categories:
-
- Carbohydrates & Derivatives
- Amino Acids & Derivatives
- 13C & 2H Sugars
- Mol File:
- Mol File
TN ANTIGEN Chemical Properties
- Melting point:
- 198-201°C
- Boiling point:
- 701.2±60.0 °C(Predicted)
- Density
- 1.51±0.1 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- Water
- form
- Solid
- pka
- 2.05±0.10(Predicted)
- color
- Off-White to Yellow
- Stability:
- HYGROSCOPIC
TN ANTIGEN Usage And Synthesis
Chemical Properties
TN ANTIGEN is Yellow Solid
Uses
TN ANTIGEN is a cancer associated carbohydrate tumor antigen which may be effective as cancer specific targets for immunotherapy as well as in the development of diagnostic monoclonal antibodies. Has been used or considered for use in human vaccines
Uses
A cancer associated carbohydrate tumor antigen which may be effective as cancer specific targets for immunotherapy as well as in the development of diagnostic monoclonal antibodies. Has been used or considered for use in human vaccines.
Definition
ChEBI: O-(N-acetyl-alpha-D-galactosaminyl)-L-serine is a non-proteinogenic L-amino acid that is N-acetyl-alpha-D-galactosamine linked via an alpha glycosidic bond to the O at position 3 of L-serine. It has a role as a tumour antigen. It is a L-serine derivative and a non-proteinogenic L-alpha-amino acid.
General Description
Tn antigen?is a truncated O-glycan, that is commonly noticed in colorectal cancer (CRC). It is usually expressed at high levels in cancer cells. Tn antigen is small in size and simple in structure. It has a non-physiological glycan structure in humans, hence it may be identified as foreign by the immune system.
Biochem/physiol Actions
Tn antigen stimulates colorectal cancer metastasis through the activation of epithelial-mesenchymal transition, mediated by H-Ras. It acts as a precursor to several significant complex O-glycans. Subpopulations of blood cells in all lineages carrying the Tn antigen results in a hematological disorder called Tn syndrome.
TN ANTIGENSupplier
- Tel
- 010-82848833 400-666-7788
- jkinfo@jkchemical.com
- Tel
- 821-50328103-801 18930552037
- 3bsc@sina.com
- Tel
- 021-50135380
- shchemsky@sina.com
- Tel
- 020-39119399 18927568969
- isunpharm@qq.com
- Tel
- 021-61415566 800-8193336
- orderCN@merckgroup.com