4,4'-DIPYRIDYL DISULFIDE Chemical Properties

Melting point:

76-78 °C(lit.)

Boiling point:

356.1±17.0 °C(Predicted)

Density 

1.3078 (rough estimate)

refractive index 

1.5500 (estimate)

storage temp. 

2-8°C

solubility 

95% ethanol: soluble5%, clear, colorless to light yellow

form 

Crystalline Powder

pka

3.60±0.26(Predicted)

color 

White to orange

BRN 

154742

InChIKey

UHBAPGWWRFVTFS-UHFFFAOYSA-N

CAS DataBase Reference

2645-22-9(CAS DataBase Reference)

NIST Chemistry Reference

Pyridine, 4,4'-dithiobis-(2645-22-9)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36-24/25

WGK Germany 

3

HS Code 

29333990

MSDS

• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

4,4'-DIPYRIDYL DISULFIDE Usage And Synthesis

Chemical Properties

white to orange crystalline powder

Uses

• Aldrithiol^?-4 was used as cosubstrate in a study to develop highly specific inhibitors against mannose-binding lectin-associated serine proteases by in vitro evolution technology:phage display.
• It was used to study the O₂ equilibria of recombinant human neuroglobin and cytoglobin measured under close to physiological conditions.
• It was used to modify gold surfaces for protein studies.

Definition

ChEBI: An organic disulfide obtained by formal oxidative dimerisation of 4-thiopyridine.

Purification Methods

Recrystallise the disulfide from H2O, EtOH, Me2CO, *C6H6 or pet ether. It has been used as a 1mM solution in EtOH for the spectrophotometric estimation of thiols. Essentially the thiol displaces half the disulfide molecule liberating the 4-mercaptopyridine (4-pyridinethiol) anion, thereby shifting the max from 324nm (of the disulfide) to 285nm (of the anion) at pH 9. (Compare with 2,2’dipyridyl disulfide above which has been used for the same purpose.) [Humphrey et al. Anal Chem 40 698 1970, Cheng & Ritchie Aust J Chem 26 1785 1973.] [Beilstein 21 II 35, for review see Aldrichimica Acta 4 33 1971.]

4,4'-DIPYRIDYL DISULFIDE(2645-22-9)Related Product Information

• S-Methyl methanethiolsulfonate
• 4,4'-Bipyridine
• Dimethyl disulfide
• 4-Mercaptopyridine
• 4,4'-DIPYRIDYL DISULFIDE
• 2,2'-Dithiodipyridine
• 3,3'-dipyridyl disulfide