Anti-OTU domain-containing protein 5 Chemical Properties

storage temp. 

-20°C

form 

buffered aqueous solution

biological source

rabbit

Safety Information

WGK Germany 

WGK 1

Storage Class

10 - Combustible liquids

Anti-OTU domain-containing protein 5 Usage And Synthesis

Biological Activity

OTU deubiquitinase 5 (OTUD5), in association with programmed cell death 5 (PDCD5), regulates p53 mediated apoptosis through deubiquitinating mechanism. It also plays a vital role in p53 stabilization and DNA damage stress response. Increase in the expression of OTUD5 is found to efficiently enhance the activation of both PDCD5 and p53. OTUD5 bound to an adaptor protein, tumor necrosis factor receptor-associated factor 3 (TRAF3), with its ovarian tumor (OTU) domain, is involved in suppression of interferon type I (IFN-I) mediated innate immune response.