Heat shock protein HSP 90-alpha Chemical Properties

storage temp. 

-20°C

form 

buffered aqueous glycerol solution

biological source

human

Water Solubility 

water: soluble

Safety Information

Hazard Codes 

Xi,T,Xn

Risk Statements 

36/37/38-61-22

Safety Statements 

26-45-53

Heat shock protein HSP 90-alpha Usage And Synthesis

Uses

Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.

Biological Activity

HSP90α (he at shock protein 90α) is involved intracellularly in the folding, assembly-disassembly and activation of multiple types of target proteins such as kinases, steroid hormone receptors and transcription factors. Extracellularly this protein is also required for neuronal and dermal fibroblast motility, and melanoma migration, invasion and metastasis. Extracellular HSP90α induces pro-invasive protein matrix metalloproteinase-2 (MMP-2), thereby promoting tumor invasiveness. This protein facilitates the migration of dermal and epidermal cells to the site of wound in a surface receptor LRP-1 (LDL receptor-related protein 1)-dependent manner, and is thus, involved in wound healing. In an early stage of the antigen processing pathway, HSP90α might function as a chaperone for precursors of pMHC I (peptide-loaded major histocompatibility I complexes).

Heat shock protein HSP 90-alpha()Related Product Information

• Recombinant Human CD52
• EMMPRIN
• SIRP alpha V8
• SF2P32
• Ammonium polyphosphate
• PROTEIN G'
• ZIP kinase
• CD28H
• fibroblast growth factor 23
• OSTEOPROTEGERIN: FC, HUMAN, RECOMBINANT