sfrp-1 Chemical Properties

storage temp. 

-20°C

form 

lyophilized

color 

white

biological source

rabbit

Safety Information

Hazard Codes 

Xn

Risk Statements 

22

WGK Germany 

WGK 3

Storage Class

11 - Combustible Solids

sfrp-1 Usage And Synthesis

Uses

Anti-SFRP1 antibody produced in rabbit is suitable for western blotting at a concentration of 0.3 μg/ml.

Biological Activity

SFRP1 (secreted frizzled-related protein 1) plays a major role in the progression of several malignancies. It also plays a vital role in antagonizing Wnt signaling. Overexpression of SFRP1 is linked with apoptosis.', 'Secreted Frizzled-related protein 1 (SFRP1) is a secreted inhibitor of Wnt signaling pathway. DNA damage or oxidative stress causes cellular senescence, which leads to the overexpression of sfrp1. This protein induces senescence phenotypes via the inactivation of Wnt signaling and activation of the retinoblastoma (Rb) pathway. Mutations or aberrant methylation in this gene impair the induction of senescence in several cancers, including breast cancer, bladder cancer, and colorectal tumorigenesis.