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Diltiazem impurity

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Diltiazem impurity Basic information

Product Name:
Diltiazem impurity
Synonyms:
  • (2S,3S)-5-(2-Aminoethyl)-2,3-dihydro-3-hydroxy-2-(4-hydroxyphenyl)-1,5-benzothiazepin-4(5H)-one
  • Diltiazem EP Impurity H
  • Diltiazem Impurity 8(Diltiazem EP Impurity H)
  • Diltiazem Impurity H
  • Diltiazem Impurity H (N,N,O-Tridesmethyl Desacetyl Diltiazem)
  • (2S,3S)-2-hydroxy-3-(4-methoxyphenyl)-3-[2-(β-N,N-dimethylaminoethylamino)phenylthio]propionic acid
  • Diltiazem EP Impurity H/ Diltiazem Related Compound H (N,N,O-Tri-Desmethyl Desacetyl Diltiazem)
  • diltiazem related compound H
CAS:
115992-91-1
MF:
C17H18N2O3S
MW:
330.4
Mol File:
115992-91-1.mol
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Diltiazem impurity Chemical Properties

Melting point:
121 - 128°C
Boiling point:
648.4±55.0 °C(Predicted)
Density 
1.365±0.06 g/cm3(Predicted)
storage temp. 
-20°C Freezer, Under inert atmosphere
solubility 
DMSO (Slightly), Methanol (Slightly, Sonicated)
form 
Solid
pka
9.81±0.30(Predicted)
color 
White to Light Yellow
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Diltiazem impurity Usage And Synthesis

Uses

(2S,3S)-5-(2-Aminoethyl)-2,3-dihydro-3-hydroxy-2-(4-hydroxyphenyl)-1,5-benzothiazepin-4(5H)-one is an impurity of diltiazem (D460620). Diltiazem Hydrochloride is a calcium channel blocker with vasodilating activity. Anti-anginal; anti-hypertensive; anti-arrhythmic (class IV).

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