2-CHLORO-4H-1,3,2-BENZODIOXAPHOSPHORIN-4-ONE Chemical Properties

Melting point:

36-40 °C (lit.)

Boiling point:

127-128 °C/11 mmHg (lit.)

Flash point:

>230 °F

storage temp. 

2-8°C

solubility 

Soluble in acetonitrile, dichloromethane, tetrahydrofuron and dimethylformamide.

form 

solid

color 

White or Colorless to Orange to Green

BRN 

1311951

Stability:

Water Sensitive

CAS DataBase Reference

5381-99-7(CAS DataBase Reference)

Safety Information

Hazard Codes 

C

Risk Statements 

14-34-37

Safety Statements 

26-36/37/39-43-45

RIDADR 

UN 3261 8/PG 1

WGK Germany 

3

F 

3-10

Hazard Note 

Corrosive

HazardClass 

8

PackingGroup 

II

HS Code 

29349990

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

2-CHLORO-4H-1,3,2-BENZODIOXAPHOSPHORIN-4-ONE Usage And Synthesis

Chemical Properties

White Crystalline Solid

Uses

2-Chloro-4H-1,3,2-benzodioxaphosphorin-4-one is a reagent used in phosphorylation and phosphitylation of alcohols and in the formation of H-phosphonates. It is also reactive cyclic phosphitylating reagent involved in fast coupling rates and hydrolytic cleavage more readily compare to that of a acyclic analog.

Uses

2-Chloro-1,3,2-benzodioxaphosphorin-4-one is used as a reagent:

• In the phosphorylation and phosphitylation of alcohols.
• In the formation of H-phosphonates which are commonly utilized in the synthesis of nucleotides.
• To synthesize nucleoside triphosphates by treating with acyl protected nucleoside.

Uses

Highly reactive cyclic phosphitylating reagent which provides fast coupling rates, and hydrolytic cleavage occurs more readily than with acyclic analogs

2-CHLORO-4H-1,3,2-BENZODIOXAPHOSPHORIN-4-ONE(5381-99-7)Related Product Information

• NAD+
• 2-Chloro-4H-1,3,2-benzodioxaphosphorin-4-one 2-oxide
• DIMETHYLCHLOROPHOSPHITE
• 2-CHLORO-4H-1,3,2-BENZODIOXAPHOSPHORIN-4-ONE