4-AMINO-N-(5-ETHYL-[1,3,4]THIADIAZOL-2-YL)-BENZENESULFONAMIDE
4-AMINO-N-(5-ETHYL-[1,3,4]THIADIAZOL-2-YL)-BENZENESULFONAMIDE Basic information
- Product Name:
- 4-AMINO-N-(5-ETHYL-[1,3,4]THIADIAZOL-2-YL)-BENZENESULFONAMIDE
- Synonyms:
-
- ethazole(pharmaceutical)
- globucid
- sulfaethidol
- sulfaethidole
- sulfaethylthiadiazole
- sulfa-perlongit
- sul-spansion
- sul-spantab
- CAS:
- 94-19-9
- MF:
- C10H12N4O2S2
- MW:
- 284.36
- EINECS:
- 202-312-4
- Mol File:
- 94-19-9.mol
4-AMINO-N-(5-ETHYL-[1,3,4]THIADIAZOL-2-YL)-BENZENESULFONAMIDE Chemical Properties
- Melting point:
- 185.5-186.0°
- Density
- 1.3410 (rough estimate)
- refractive index
- 1.6440 (estimate)
- pka
- pKa 5.36(H2O t = 37) (Uncertain)
- Water Solubility
- 215mg/L(20 ºC)
Safety Information
- Hazard Codes
- Xi
- HazardClass
- IRRITANT
- Toxicity
- LD50 intraperitoneal in mouse: 1459mg/kg
4-AMINO-N-(5-ETHYL-[1,3,4]THIADIAZOL-2-YL)-BENZENESULFONAMIDE Usage And Synthesis
Originator
Sul-Spansion,SKF,US,1956
Definition
ChEBI: 4-amino-N-(5-ethyl-1,3,4-thiadiazol-2-yl)benzenesulfonamide is a member of benzenes and a sulfonamide.
Manufacturing Process
0.163 mol of 2-amino-5-ethyl-1,3,4-thiadiazole was covered with 43 parts of anhydrous pyridine. To the mixture was added 50 parts (0.214 mol) of pacetylaminobenzenesulfonyl chloride with vigorous shaking at 50°C to 60°C. The reaction mixture was then heated to 125°C. When the mixture had cooled somewhat it was placed in a Claisen flask and 27.6 parts (0.69 mol) of sodium hydroxide dissolved in 110 parts of water was added through a dropping funnel while distilling off a mixture of pyridine and water. The distillation was stopped when the temperature reached 100°C and the residual liquor in the flask heated at 95°C for 30 minutes.The reaction mixture was then poured into 1,650 parts of hot water, the pH adjusted to 8 to 9, decolorizing charcoal was added and the whole was heated on the steam for 15 minutes. The charcoal was filtered off and the hot filtrate neutralized and cooled. The 2-(sulfanilamido)-5-ethyl-1,3,4-thiadiazole was purified by repeated crystallization from boiling water.
Therapeutic Function
Antibacterial
4-AMINO-N-(5-ETHYL-[1,3,4]THIADIAZOL-2-YL)-BENZENESULFONAMIDESupplier
- Tel
- 010-82848833 400-666-7788
- jkinfo@jkchemical.com
- Tel
- 86-027-67849912
- sales@chemwish.com
- Tel
- +91-22-26355700
- info@clearsynth.com
- Tel
- 022-6537-8550 15522853686
- sales@altasci.com.cn
- Tel
- 027-67849912
- sales@chemwish.com
4-AMINO-N-(5-ETHYL-[1,3,4]THIADIAZOL-2-YL)-BENZENESULFONAMIDE(94-19-9)Related Product Information
- Sulfadimethoxine sodium salt
- 4-{[(4-chloroanilino)carbonyl]amino}-N-(5-ethyl-1,3,4-thiadiazol-2-yl)benzenesulfonamide
- 4-{[3-(1,3-benzodioxol-5-yl)-3-oxo-1-propenyl]amino}-N-(5-ethyl-1,3,4-thiadiazol-2-yl)benzenesulfonamide
- 4-{[(cinnamoylamino)carbothioyl]amino}-N-(5-ethyl-1,3,4-thiadiazol-2-yl)benzenesulfonamide
- 4-{[3-(4-ethoxyphenyl)-3-oxo-1-propenyl]amino}-N-(5-ethyl-1,3,4-thiadiazol-2-yl)benzenesulfonamide
- 4-{[(E)-(4-chlorophenyl)methylidene]amino}-N-(5-ethyl-1,3,4-thiadiazol-2-yl)benzenesulfonamide
- 4-{[(E)-1,3-benzodioxol-5-ylmethylidene]amino}-N-(5-ethyl-1,3,4-thiadiazol-2-yl)benzenesulfonamide
- 4-{[2-(5-chloro-1,3-benzoxazol-2-yl)-3-oxo-1-propenyl]amino}-N-(5-ethyl-1,3,4-thiadiazol-2-yl)benzenesulfonamide
- 4-{[2-(1,3-benzoxazol-2-yl)-3-oxo-1-propenyl]amino}-N-(5-ethyl-1,3,4-thiadiazol-2-yl)benzenesulfonamide
- 3-[4-(5-ETHYL-[1,3,4]THIADIAZOL-2-YLSULFAMOYL)-PHENYLCARBAMOYL]-ACRYLIC ACID
- SULFAETHIDOLE SODIUM
- Glyprothiazol
- glybuthiazol
- 4-AMINO-N-(5-ETHYL-[1,3,4]THIADIAZOL-2-YL)-BENZENESULFONAMIDE