1-(2-ETHYLPHENOXY)-3-[[(1S)-1,2,3,4-TETRAHYDRO-1-NAPHTHALENYL]AMINO]-(2S)-2-PROPANOL HYDROCHLORIDE Chemical Properties

storage temp. 

Inert atmosphere,Room Temperature

solubility 

DMSO: >10mg/mL

form 

powder

color 

white

Safety Information

Safety Statements 

22-24/25

WGK Germany 

3

1-(2-ETHYLPHENOXY)-3-[[(1S)-1,2,3,4-TETRAHYDRO-1-NAPHTHALENYL]AMINO]-(2S)-2-PROPANOL HYDROCHLORIDE Usage And Synthesis

Uses

SR 59230A was used in the identification of β-adrenoceptors in rat aorta.³ It was tested as a potential therapeutic agent in improving cardiac function in rat model of heart failure.⁴

Hazard

A poison.

Biological Activity

Potent and selective β 3 adrenoceptor antagonist (IC 50 values are 40, 408 and 648 nM for β 3 , β 1 and β 2 receptors respectively). Orally active in vivo . Also available as part of the β -Adrenoceptor Antagonist Tocriset™ .

Biochem/physiol Actions

SR 59230A is a β3-adrenoceptor antagonist. It has high affinity for the β3 adrenoceptors occurring in human gut that affect the function of human colonic circular smooth muscle.1 It is reported that SR 59230A inhibits the Kir2.1-2.3 cardiac potassium channels.2

1-(2-ETHYLPHENOXY)-3-[[(1S)-1,2,3,4-TETRAHYDRO-1-NAPHTHALENYL]AMINO]-(2S)-2-PROPANOL HYDROCHLORIDE(174689-39-5)Related Product Information

• (S)-N-METHYL-1,2,3,4-TETRAHYDRONAPHTHALEN-1-AMINE
• (S)--1-AMINOTETRALINE HCL
• 1-(2-ETHYLPHENOXY)-3-[[(1S)-1,2,3,4-TETRAHYDRO-1-NAPHTHALENYL]AMINO]-(2S)-2-PROPANOL HYDROCHLORIDE
• (S)-(-)-1-BENZYLAMINO-3-PHENOXY-2-PROPANOL