CFI-400936
CFI-400936 Basic information
- Product Name:
- CFI-400936
- Synonyms:
-
- CFI-400936
- 2-(dimethylamino)-2-(2-ethylphenyl)-N-[3-(3-sulfamoylphenyl)-1H-indazol-5-yl]acetamide
- Benzeneacetamide, N-[3-[3-(aminosulfonyl)phenyl]-1H-indazol-5-yl]-α-(dimethylamino)-2-ethyl-
- CAS:
- 1338793-07-9
- MF:
- C25H27N5O3S
- MW:
- 477.58
- Mol File:
- 1338793-07-9.mol
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CFI-400936 Chemical Properties
- Density
- 1.337±0.06 g/cm3(Predicted)
- pka
- 9.82±0.60(Predicted)
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CFI-400936 Usage And Synthesis
Description
CFI-400936 is a potent and selective TTK inhibitor with potential anticancer activity. This potent inhibitor of TTK (IC50=3.6nM) demonstrated good activity in cell based assay and selectivity against a panel of human kinases.
Uses
CFI-400936 is a potent TTK inhibitor with an IC50 of 3.6 nM. CFI-400936 has antitumor activity[1].
References
[1] Laufer R, et al. Discovery of inhibitors of the mitotic kinase TTK based on N-(3-(3-sulfamoylphenyl)-1H-indazol-5-yl)-acetamides and carboxamides. Bioorg Med Chem. 2014 Sep 1;22(17):4968-97. DOI:10.1016/j.bmc.2014.06.027