Basic information Safety Supplier Related

VU 0409551

Basic information Safety Supplier Related

VU 0409551 Basic information

Product Name:
VU 0409551
Synonyms:
  • VU 0409551
  • JNJ-46778212
  • [6,7-Dihydro-2-(phenoxymethyl)oxazolo[5,4-c]pyridin-5(4H)-yl](fluorophenyl)methanone
  • (4-fluorophenyl)-[2-(phenoxymethyl)-6,7-dihydro-4H-oxazolo[5,4-c]pyridin-5-yl]methanone
  • Methanone, [6,7-dihydro-2-(phenoxymethyl)oxazolo[5,4-c]pyridin-5(4H)-yl](4-fluorophenyl)-
  • JNJ 46778212,JNJ46778212
  • (4-Fluorophenyl)(2-(phenoxymethyl)-6,7-dihydrooxazolo[5,4-c]pyridin-5(4H)-yl)methanone
  • JNJ-46778212, 10 mM in DMSO
CAS:
1363281-27-9
MF:
C20H17FN2O3
MW:
352.36
Mol File:
1363281-27-9.mol
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VU 0409551 Chemical Properties

Boiling point:
545.8±50.0 °C(Predicted)
Density 
1.308±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: soluble; Ethanol: soluble
form 
A crystalline solid
pka
1.35±0.20(Predicted)
color 
Light yellow to yellow
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VU 0409551 Usage And Synthesis

Uses

VU 0409551 is an mGlu5 allosteric modulator.

Biological Activity

VU0409551 (JNJ-46778212) is an orally available, potent and selective biased metabotropic glutamate receptor subtype 5 positive allosteric modulator (mGlu5 PAM). VU0409551 (JNJ-46778212) selectively potentiates mGlu5 coupling to Gaq-mediated signaling without modulation of NMDAR currents in hippocampal neurons. VU0409551 exhibits potent antipsychotic-like and cognition enhancing activity in animal models.

in vivo

In oral brain/plasma studies, JNJ-46778212 displays excellent CNS penetration[1]. JNJ-46778212 enhances NMDAR function and rescues long-term potentiation in hippocampal slices obtained from SR?/? mice. The administration of JNJ-46778212 to SR?/? mice reverses their deficits in several neuroplasticity signaling pathways and improves their contextual fear memory[2].

IC 50

mGlu5 Receptor: 260 nM (EC50)

storage

Store at +4°C

VU 0409551Supplier

Guangzhou Zhiya Chemdrugs Co.,Ltd
Tel
18122150900
Email
sculk28@163.com
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Email
3008007409@qq.com
ShangHai Biochempartner Co.,Ltd
Tel
177-54423994 17754423994
Email
2853530910@QQ.com
Amadis Chemical Company Limited
Tel
571-89925085
Email
sales@amadischem.com
Chuzhou KeMail Chemical Technology Co., Ltd
Tel
0550-5196001 15000891977
Email
wj520wjxby@126.com