Rbin-2 - Ribozinoindole-2 Chemical Properties

Boiling point:

524.3±60.0 °C(Predicted)

Density 

1?+-.0.1 g/cm3(Predicted)

storage temp. 

2-8°C

solubility 

DMSO: 1mg/mL, clear (warmed)

form 

Solid

pka

9.30±0.50(Predicted)

color 

Off-white to light yellow

Rbin-2 - Ribozinoindole-2 Usage And Synthesis

Description

Rbin-2 is a novel cell penetrant, potent, selective and reversible inhibitor of Midasin, inhibiting eukaryotic ribosome biogenesis and directly targeting AAA+ ATPase Midasin.

Uses

Rbin-2 is a potent, reversible and selective inhibitor of Midasin (Mdn1), an enzyme belonging to the AAA+ (ATPases associated with diverse cellular activities) protein family. Rbin-2 inhibits eukaryotic ribosome biogenesis and is a powerful probe for the eukaryotic ribosome assembly[1].

References

[1] Kawashima SA, et al. Potent, Reversible, and Specific Chemical Inhibitors of Eukaryotic Ribosome Biogenesis. Cell. 2016 Oct 6;167(2):512-524.e14. DOI:10.1016/j.cell.2016.08.070