5-((2,4-dimethoxynaphthalen-1-yl)methylene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
5-((2,4-dimethoxynaphthalen-1-yl)methylene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione Basic information
- Product Name:
- 5-((2,4-dimethoxynaphthalen-1-yl)methylene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
- Synonyms:
-
- 5-[(2,4-Dimethoxy-1-naphthalenyl)methylene]dihydro-2-thioxo-4,6(1H,5H)-pyrimidinedione
- IT 901;IT901;IT-901;1584121-99-2
- 5-((2,4-dimethoxynaphthalen-1-yl)methylene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
- IT901
- 4,6(1H,5H)-Pyrimidinedione, 5-[(2,4-dimethoxy-1-naphthalenyl)methylene]dihydro-2-thioxo-
- IT 901,IT901
- 5-[(2,4-dimethoxynaphthalen-1-yl)methylidene]-2-sulfanylidene-1,3-diazinane-4,6-dione
- CAS:
- 1584121-99-2
- MF:
- C17H14N2O4S
- MW:
- 342.37
- Mol File:
- 1584121-99-2.mol
More
Less
5-((2,4-dimethoxynaphthalen-1-yl)methylene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione Chemical Properties
- Density
- 1.43±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMF:33.0(Max Conc. mg/mL);96.39(Max Conc. mM)
DMSO:33.0(Max Conc. mg/mL);96.39(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:6):0.14(Max Conc. mg/mL);0.41(Max Conc. mM) - form
- A crystalline solid
- pka
- 4.68±0.20(Predicted)
- color
- Orange to red
More
Less
5-((2,4-dimethoxynaphthalen-1-yl)methylene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione Usage And Synthesis
Uses
IT 901 is a bioactive naphthalenethiobarbiturate derivative that potently inhibits the NF-κB subunit c-?Rel. IT 901 also revealed antitumor properties in vitro and in vivo.
in vivo
IT-901 (24 mg/kg; IP; every other day for 2 weeks) has an effective treatment of acute GVHD without impairing anti-tumor activity[1].
IT-901 (12-20 mg/kg; IP) improves the PK profile by increasing T1/2 and Cmax[1].
| Animal Model: | BALB/C-Tg (NFkB-RE-luc)-Xen mice with 6-9 weeks old[1] |
| Dosage: | 24 mg/kg |
| Administration: | IP; every other day for 2 weeks |
| Result: | Had an effective treatment of acute GVHD without impairing anti-tumor activity. |
IC 50
NF-κB: 0.1 μM (IC50); c-Rel: 3 μM (IC50)
5-((2,4-dimethoxynaphthalen-1-yl)methylene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dioneSupplier
ShangHai Caerulum Pharma Discovery Co., Ltd.
- Tel
- 18149758185
- sales-cpd@caerulumpharma.com
Shanghai Lollane Biological Technology Co.,Ltd.
- Tel
- 021-52996696，15000506266 15000506266
Shanghai EFE Biological Technology Co., Ltd.
- Tel
- 021-65675885 18964387627
- info@efebio.com
Amadis Chemical Company Limited
- Tel
- 571-89925085
- sales@amadischem.com
Twochem Co.Ltd.
- Tel
- 021-58111628 15800915896
- sales@twochem.com