2-Pyrrolidinepropanoic acid, 1-[(1,1-dimethylethoxy)carbonyl]-β-hydroxy-α-methyl-, phenylmethyl ester, [2S-[2R*(αR*,βS*)]]- (9CI) CAS#: 173653-47-9

2-Pyrrolidinepropanoic acid, 1-[(1,1-dimethylethoxy)carbonyl]-β-hydroxy-α-methyl-, phenylmethyl ester, [2S-[2R(αR,βS*)]]- (9CI)

Basic information Safety Supplier Related

2-Pyrrolidinepropanoic acid, 1-[(1,1-dimethylethoxy)carbonyl]-β-hydroxy-α-methyl-, phenylmethyl ester, [2S-[2R(αR,βS*)]]- (9CI) Basic information

Product Name:

2-Pyrrolidinepropanoic acid, 1-[(1,1-dimethylethoxy)carbonyl]-β-hydroxy-α-methyl-, phenylmethyl ester, [2S-[2R*(αR*,βS*)]]- (9CI)

Synonyms:

2-Pyrrolidinepropanoic acid, 1-[(1,1-dimethylethoxy)carbonyl]-β-hydroxy-α-methyl-, phenylmethyl ester, [2S-[2R*(αR*,βS*)]]- (9CI)
tert-butyl (S)-2-((1R,2S)-3-(benzyloxy)-1-hydroxy-2-methyl-3-oxopropyl)pyrrolidine-1-carboxylate
benzyl (2S,3R,2'S)-3-(N-tert-butoxycarbonyl-2'-pyrrolidinyl)-3-hydroxy-2-methylpropanoate
2-Pyrrolidinepropanoicacid,1-[(1,1-dimethylethoxy)carbonyl]-β-hydroxy-α-methyl-,phenylmethylester,[2S-[2R*(αR*,βS*)]]-(9CI)
Monomethyl auristatin E intermediate-15

CAS:

173653-47-9

MF:

C20H29NO5

MW:

363.45

Mol File:

173653-47-9.mol

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2-Pyrrolidinepropanoic acid, 1-[(1,1-dimethylethoxy)carbonyl]-β-hydroxy-α-methyl-, phenylmethyl ester, [2S-[2R(αR,βS*)]]- (9CI) Chemical Properties

Boiling point:: 492.3±20.0 °C(Predicted)
Density: 1.156±0.06 g/cm3(Predicted)
storage temp.: Storage temp. 2-8°C
form: Oil
pka: 13.99±0.20(Predicted)
color: Colorless to light yellow

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2-Pyrrolidinepropanoic acid, 1-[(1,1-dimethylethoxy)carbonyl]-β-hydroxy-α-methyl-, phenylmethyl ester, [2S-[2R(αR,βS*)]]- (9CI) Usage And Synthesis

Uses

Monomethyl auristatin E intermediate-15 is an intermediate reagent in the synthesis of Monomethyl auristatin E (HY-15162). Monomethyl auristatin E (MMAE) is a microtubule/tubulin inhibitor with anticancer activity. MMAE is widely used as the cytotoxic component (ADC Cytotoxin) of antibody-drug conjugates (ADCs)[1].

References

[1] Lisa Buckel, et al. Tumor radiosensitization by monomethyl auristatin E: mechanism of action and targeted delivery. Cancer Res. 2015 Apr 1;75(7):1376-87. DOI:10.1158/0008-5472.CAN-14-1931

2-Pyrrolidinepropanoic acid, 1-[(1,1-dimethylethoxy)carbonyl]-β-hydroxy-α-methyl-, phenylmethyl ester, [2S-[2R(αR,βS*)]]- (9CI)Supplier

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