GW-870086
GW-870086 Basic information
- Product Name:
- GW-870086
- Synonyms:
-
- CPD1550
- GW870086
- cyanomethyl (6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-17-(2,2,3,3-tetramethylcyclopropanecarbonyl)oxy-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthrene-17-carboxylate
- cyanomethyl (6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-17-((2,2,3,3-tetramethylcyclopropane-1-carbonyl)oxy)-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cycl openta[a]phenanthrene-17-carboxylate
- GW-870086,Glucocorticoid Receptor,GW 870086,Inhibitor,inhibit,GW870086
- Androsta-1,4-diene-17-carboxylic acid, 6,9-difluoro-11-hydroxy-16-methyl-3-oxo-17-[[(2,2,3,3-tetramethylcyclopropyl)carbonyl]oxy]-, cyanomethyl ester, (6α,11β,16α,17α)-
- AXR-159
- GW-870086, 10 mM in DMSO
- CAS:
- 827319-43-7
- MF:
- C31H39F2NO6
- MW:
- 559.6412664
- Mol File:
- 827319-43-7.mol
More
Less
GW-870086 Chemical Properties
- Boiling point:
- 630.6±55.0 °C(Predicted)
- Density
- 1.28±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- pka
- 12.55±0.70(Predicted)
- form
- Solid
- color
- White to off-white
More
Less
GW-870086 Usage And Synthesis
Uses
GW-870086 is a potent anti-inflammatory agent, acting as a glucocorticoid receptor agonist, with a pIC50 of 10.1 in A549 cells expressing NF-κB.
References
[1] Uings IJ, et al. Discovery of GW870086: a potent anti-inflammatory steroid with a unique pharmacological profile. Br J Pharmacol. 2013 Jul;169(6):1389-403. DOI:10.1111/bph.12232
[2] Stamer WD, et al. Unique response profile of trabecular meshwork cells to the novel selective glucocorticoid receptor agonist, GW870086X. Invest Ophthalmol Vis Sci. 2013 Mar 1;54(3):2100-7. DOI:10.1167/iovs.12-11298
GW-870086Supplier
ShangHai Caerulum Pharma Discovery Co., Ltd.
- Tel
- 18149758185
- sales-cpd@caerulumpharma.com
Bide Pharmatech Ltd.
- Tel
- 400-164-7117 13681763483
- product02@bidepharm.com
Shanghai Lollane Biological Technology Co.,Ltd.
- Tel
- 021-52996696，15000506266 15000506266
Shanghai EFE Biological Technology Co., Ltd.
- Tel
- 021-65675885 18964387627
- info@efebio.com
Amadis Chemical Company Limited
- Tel
- 571-89925085
- sales@amadischem.com