CU-CPT-9a Chemical Properties

Boiling point:

452.6±45.0 °C(Predicted)

Density 

1.287±0.06 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml

form 

A crystalline solid

pka

8.46±0.20(Predicted)

CU-CPT-9a Usage And Synthesis

Description

CU-CPT9b is an antagonist of toll-like receptor 8 (TLR8; K_d = 21 nM). It inhibits activation of NF-ĸB induced by the TLR8 agonist R-848 in TLR8-overexpressing HEK-Blue cells with an IC₅₀ value of 0.7 nM.

Uses

CU-CPT9a is a potent TLR8 inhibitor (IC50 = 0.5 nM and Kd = 21 nM). Stabilizes the TLR8 dimer in its resting state, preventing activation. Suppresses TLR8-mediated proinflammatory signaling in various cell lines and human primary cells.

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