4-(7-methoxyquinolin-4-yl)-2-methylphenol Chemical Properties

Boiling point:

429.7±45.0 °C(Predicted)

Density 

1.201±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Store in freezer, under -20°C

solubility 

DMF: 30 mg/ml; DMF:PBS (pH 7.2) (1:9): 0.1 mg/ml; DMSO: 10 mg/ml; Ethanol: 5 mg/ml

form 

A crystalline solid

pka

8.47±0.20(Predicted)

color 

Light yellow to yellow

4-(7-methoxyquinolin-4-yl)-2-methylphenol Usage And Synthesis

Uses

CU-CPT9a is a potent TLR8 inhibitor (IC50 = 0.5 nM and Kd = 21 nM). Stabilizes the TLR8 dimer in its resting state, preventing activation. Suppresses TLR8-mediated proinflammatory signaling in various cell lines and human primary cells.

Biological Activity

CU-CPT9a is a potent and selective inhibitor of Toll-like receptor 8 (TLR8). It binds to TLR8 at a site different from current small-molecule TLR7/8 agonists, stabilizing the TLR8 dimer in its resting state, thus preventing TLR8 activation It exhibited an IC50 value of 0.5 nM and blocked TLR8 activation induced by either resiquimod (R848) or ssRNA without affecting the closely related TLR7 or cells expressing other TLRs. CU-CPT9a also suppressed TNF-α levels in a dose-dependent manner in cells from patients with rheumatoid arthritis.

storage

Store at -20°C

4-(7-methoxyquinolin-4-yl)-2-methylphenol(2165340-32-7)Related Product Information

• Tilorone dihydrochloride
• CU-CPT17e
• CU-CPT-8m
• CU-CPT-9a