ChemicalBook > CAS DataBase List > 4-(7-methoxyquinolin-4-yl)-2-methylphenol

4-(7-methoxyquinolin-4-yl)-2-methylphenol

Product Name
4-(7-methoxyquinolin-4-yl)-2-methylphenol
CAS No.
2165340-32-7
Chemical Name
4-(7-methoxyquinolin-4-yl)-2-methylphenol
Synonyms
CU-CPT-9b;cas 2165340-32-7;CU-CPT-9B, CPD2004;CU-CPT9a >=98% (HPLC);CU-CPT-9a, 10 mM in DMSO;(7-methoxyquinolin-4-yl)-2-methylphenol;2-Methyl-4-(7-methoxy-4-quinolinyl)phenol;4-(7-methoxyquinolin-4-yl)-2-methylphenol;CU-CPT-9B;CAS 2165340-32-7 ;TLR8 INHIBITOR;Phenol, 4-(7-methoxy-4-quinolinyl)-2-methyl-
CBNumber
CB53369684
Molecular Formula
C17H15NO2
Formula Weight
265.31
MOL File
2165340-32-7.mol
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4-(7-methoxyquinolin-4-yl)-2-methylphenol Property

Boiling point:
429.7±45.0 °C(Predicted)
Density 
1.201±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Store in freezer, under -20°C
solubility 
DMF: 30 mg/ml; DMF:PBS (pH 7.2) (1:9): 0.1 mg/ml; DMSO: 10 mg/ml; Ethanol: 5 mg/ml
form 
A crystalline solid
pka
8.47±0.20(Predicted)
color 
Light yellow to yellow
InChI
1S/C17H15NO2/c1-11-9-12(3-6-17(11)19)14-7-8-18-16-10-13(20-2)4-5-15(14)16/h3-10,19H,1-2H3
InChIKey
HNYBTVKYLVLWCB-UHFFFAOYSA-N
SMILES
CC1=CC(C2=CC=NC3=CC(OC)=CC=C23)=CC=C1O
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Safety

WGK Germany 
WGK 3
Storage Class
11 - Combustible Solids
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
28722
Product name
CU-CPT9a
Packaging
5mg
Price
$100
Updated
2024/03/01
Cayman Chemical
Product number
28722
Product name
CU-CPT9a
Packaging
25mg
Price
$381
Updated
2024/03/01
Cayman Chemical
Product number
28722
Product name
CU-CPT9a
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
28722
Product name
CU-CPT9a
Packaging
10mg
Price
$184
Updated
2024/03/01
TRC
Product number
C852008
Product name
CU-CPT9a
Packaging
2.5mg
Price
$130
Updated
2021/12/16
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4-(7-methoxyquinolin-4-yl)-2-methylphenol Chemical Properties,Usage,Production

Uses

CU-CPT9a is a potent TLR8 inhibitor (IC50 = 0.5 nM and Kd = 21 nM). Stabilizes the TLR8 dimer in its resting state, preventing activation. Suppresses TLR8-mediated proinflammatory signaling in various cell lines and human primary cells.

Biological Activity

CU-CPT9a is a potent and selective inhibitor of Toll-like receptor 8 (TLR8). It binds to TLR8 at a site different from current small-molecule TLR7/8 agonists, stabilizing the TLR8 dimer in its resting state, thus preventing TLR8 activation It exhibited an IC50 value of 0.5 nM and blocked TLR8 activation induced by either resiquimod (R848) or ssRNA without affecting the closely related TLR7 or cells expressing other TLRs. CU-CPT9a also suppressed TNF-α levels in a dose-dependent manner in cells from patients with rheumatoid arthritis.

IC 50

TLR8: 0.5 nM (IC50)

storage

Store at -20°C

4-(7-methoxyquinolin-4-yl)-2-methylphenol Preparation Products And Raw materials

Raw materials

Preparation Products

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4-(7-methoxyquinolin-4-yl)-2-methylphenol Suppliers

China 71 India 1 United Kingdom 1 United States 6 Global 79
ShangHai Caerulum Pharma Discovery Co., Ltd.
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18149758185 18149758185
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sales-cpd@caerulumpharma.com
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China
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Bide Pharmatech Ltd.
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400-400-164-7117 18317119277
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+86-21-61629029
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product02@bidepharm.com
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China
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Shanghai Lollane Biological Technology Co.,Ltd.
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021-52996696，15000506266 15000506266
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+86-21-52996696
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China
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Shanghai EFE Biological Technology Co., Ltd.
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021-65675885 18964387627
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021-65675885
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China
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Shanghai YuanYe Biotechnology Co., Ltd.
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Tianjin Kailiqi Biotechnology Co., Ltd.
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022-23754520
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klq@cw-bio.com
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China
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ShangHai Biochempartner Co.,Ltd
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Shanghai Rechem science Co., Ltd.
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021-31433387 15618786686
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QQ:1369748377
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sales@rechemscience.com
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China
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Shanghai SuperLan Chemcial Technique Centre
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0-2022843681 15618226720
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+86-21-51601218
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chaolaichem@foxmail.com
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China
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Beijing Solarbio Science & Tecnology Co., Ltd.
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010-50973130 18101056239
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3193328036@qq.com
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China
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2165340-32-7, 4-(7-methoxyquinolin-4-yl)-2-methylphenolRelated Search:

Tilorone dihydrochloride CU-CPT17e CU-CPT-8m CU-CPT-9a

  • 4-(7-methoxyquinolin-4-yl)-2-methylphenol
  • CU-CPT-9B, CPD2004
  • CU-CPT-9b
  • 2-Methyl-4-(7-methoxy-4-quinolinyl)phenol
  • cas 2165340-32-7
  • CU-CPT-9B;CAS 2165340-32-7 ;TLR8 INHIBITOR
  • Phenol, 4-(7-methoxy-4-quinolinyl)-2-methyl-
  • CU-CPT9a >=98% (HPLC)
  • Toll-like Receptor (TLR),inhibit,Inhibitor,CU CPT 9a,CUCPT9a
  • CU-CPT-9a, 10 mM in DMSO
  • (7-methoxyquinolin-4-yl)-2-methylphenol
  • 2165340-32-7