5α-Pregnane-3β,6α-diol-20-one Chemical Properties

Melting point:

202-203 °C

Boiling point:

469.7±30.0 °C(Predicted)

Density 

1.117±0.06 g/cm3(Predicted)

pka

14.72±0.70(Predicted)

form 

Solid

color 

White to off-white

5α-Pregnane-3β,6α-diol-20-one Usage And Synthesis

Uses

5α-Pregnane-3β,6α-diol-20-one is a mitogenic metabolite of progesterone, and it can be produced in starved androgen-responsive prostate cancer cells.

References

[1] Zhang J, et al. Progesterone metabolism in human fibroblasts is independent of P-glycoprotein levels and Niemann-Pick type C disease. J Steroid Biochem Mol Biol. 1999 Sep-Oct;70(4-6):123-31. DOI:10.1016/s0960-0760(99)00107-7
[2] de Mello Martins AGG, et al. CYP17A1-independent production of the neurosteroid-derived 5α-pregnan-3β,6α-diol-20-one in androgen-responsive prostate cancer cell lines under serum starvation and inhibition by Abiraterone. J Steroid Biochem Mol Biol. 2017 Nov;174:183-191. DOI:10.1016/j.jsbmb.2017.09.006