GNE 220
GNE 220 Basic information
- Product Name:
- GNE 220
- Synonyms:
-
- GNE 220
- 5H-Pyrido[3',2':4,5]pyrrolo[3,2-d]pyrimidine, 4-methyl-8-[4-(4-methyl-1-piperazinyl)phenyl]-2-(1-methyl-1H-pyrazol-4-yl)-
- 6-Methyl-12-[4-(4-methylpiperazin-1-yl)phenyl]-4-(1-methylpyrazol-4-yl)-3,5,8,10-tetrazatricyclo[7.4.0.02,7]trideca-1(9),2,4,6,10,12 -hexaene
- CAS:
- 1199590-75-4
- MF:
- C25H26N8
- MW:
- 438.52754
- Mol File:
- 1199590-75-4.mol
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GNE 220 Chemical Properties
- Density
- 1.38±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- pka
- 11.21±0.50(Predicted)
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GNE 220 Usage And Synthesis
Uses
GNE-220 is a potent and selective inhibitor of MAP4K4 with an IC50 of 7 nM.
IC 50
MAP4K4: 7 nM (IC50); MAP4K5: 9 nM (IC50); MAP4K6: 1.1 μM (IC50)
References
[1] Vitorino P, et al. MAP4K4 regulates integrin-FERM binding to control endothelial cell motility. Nature. 2015 Mar 26;519(7544):425-30. DOI:10.1038/nature14323
GNE 220Supplier
Fan De(Beijing) Biotechnology Co., Ltd.
- Tel
- 15911056312
- liming@bio-fount.com
TargetMol Chemicals Inc.
- Tel
- +1-781-999-5354; +17819995354
- marketing@targetmol.com
HANGZHOU CLAP TECHNOLOGY CO.,LTD
- Tel
- 86-571-88216897,88216896 13588875226
- sales@hzclap.com
Shanghai hongqu biomedical technology co. LTD
- Tel
- 88888888888
- hongquchem@qq.com
Suzhou youruike Chemical Pharmaceutical Technology Co., Ltd
- Tel
- 15317229551
- 15151849396@163.com