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N-FORMYL-L-HISTIDINE

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N-FORMYL-L-HISTIDINE Basic information

Product Name:
N-FORMYL-L-HISTIDINE
Synonyms:
  • FOR-HIS-OH
  • N-FORMYL-L-HISTIDINE
  • N-ALPHA-FORMYL-L-HISTIDINE
  • Formylhistidine
  • 2-formamido-3-(1H-imidazol-5-yl)propanoic acid
  • Einecs 239-248-1
  • (S)-2-ForMaMido-3-(1H-iMidazol-4-yl)propanoic acid
  • (2S)-2-(Formylamino)-3-(1H-imidazol-4-yl)propanoic acid
CAS:
15191-21-6
MF:
C7H9N3O3
MW:
183.16
EINECS:
239-248-1
Mol File:
15191-21-6.mol
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N-FORMYL-L-HISTIDINE Chemical Properties

Melting point:
202.0 to 206.0 °C
Boiling point:
644.5±50.0 °C(Predicted)
Density 
1.431±0.06 g/cm3(Predicted)
refractive index 
58 ° (C=2, H2O)
storage temp. 
Sealed in dry,Room Temperature
form 
powder to crystal
pka
2.85±0.10(Predicted)
color 
White to Almost white
Water Solubility 
almost transparency
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Safety Information

HS Code 
2922.49.4950
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N-FORMYL-L-HISTIDINE Usage And Synthesis

Uses

N-Formyl-L-histidine shows binding affinity to histidyl-tRNA synthetase with a Ki value of 4.6 μM. N-Formyl-L-histidine shows a competitive inhibition against L-histidine ammonia-lyase, inhibits urocanic acid formation from L-histidine with a Ki value of 4.26 mM[1][2].

References

[1] Lepore GC, et al. Histidyl-tRNA synthetase from Salmonella typhimurium: specificity in the binding of histidine analogues. Eur J Biochem. 1975 Aug 15;56(2):369-74. DOI:10.1111/j.1432-1033.1975.tb02242.x
[2] Shibatani T, et al. Crystalline L-histidine ammonia-lyase of Achromobacter liquidum. Crystallization and enzymic properties. Eur J Biochem. 1975 Jun 16;55(1):263-9. DOI:10.1111/j.1432-1033.1975.tb02159.x

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