DOXACURIUM CHLORIDE Usage And Synthesis

Reaction

Ligand for the palladium catalyzed aqueous Lipshutz-Negishi cross-coupling of alkyl halides with aryl electrophiles.

Description

Doxacurium chloride is an injectable, noncumulative, nondepolarizing neuromuscular blocking agent which exhibits no significant cardiovascular effects. It is a mixture of (lR, l′S, 2S, 2′R), (lR, l′R, 2S, 2′s) and (lS, l′S, 2R, 2′R) isomers of a bis-benzylisoquinolinium diester.Doxacurium chloride provides satisfactory intubation with duration of action similar to d-tubocurarine or pancuronium. However, it is reported to be 2 to 3 times as potent as pancuronium.

Originator

Wellcome (United Kingdom)

Uses

Neuromuscular blocking agent.

Uses

Doxacurium Chloride is a nondepolarizing neuromuscular blocking agent that is minimally hydrolyzed by human plasma cholinesterase.

brand name

Nuromax (Abbott).

General Description

The molecular structure of doxacuriumchloride, 1,2,3,4-tetrahydro-2-(3-hydroxypropyl)-6,7,8-trimethoxy2-methyl-1-(3,4,5-trimethoxybenzyl) isoquinoliniumchloride succinate (Nuromax), provides thepossibility for 10 stereoisomers: 4 d,l pairs and two mesoforms. Of the 10 stereoisomers, 3 are all-trans configuration,and these are the only active ones. Doxacurium chlorideis a long-acting nondepolarizing blocking agent. The drugdiffers from drugs such as gallium and pancuronium in thatit has no vagolytic activity. It is used as a skeletal musclerelaxant in surgical procedures expected to last longer than90 minutes.

Pharmacokinetics

Doxacurium is a mixture of three trans, trans-stereoisomers, a dl pair [(1R,1′R,2S,2′S) and (1S,1′S,2R,2′R)] and a meso form (1R,1′S,2S,2′R). Doxacurium is hydrophilic, has a small volume of distribution, and is distributed primarily to extracellular fluids. It is not metabolized by plasma cholinesterase or hepatic enzymes and does not undergo Hofmann elimination.

DOXACURIUM CHLORIDE(106819-53-8)Related Product Information

• 2,4-Dimethoxybenzylamine hydrochloride
• (S)-1-(2-Methoxyphenyl)ethylamine
• (+/-)-Tetrahydropapaverine
• 1,4-BUTANEDIOL BIS(3-AMINOPROPYL) ETHER
• R-tetrahydropapaverine HCl
• Tetrahydropapaverine hydrochloride
• PHENOL, 2-METHOXY-5-[2-(3,4,5-TRIMETHOXYPHENYL)ETHYL]-
• (R)-1-(2-Methoxyphenyl)ethylamine
• (R)-1-(3-Methoxyphenyl)ethylamine
• Trimethoxyamphetamine
• 5'-Methoxylaudanosine
• DOXACURIUM CHLORIDE
• 3,4,5-TRIMETHOXYPHENETHYLAMINE, HYDROCHLORIDE
• Benzenemethanamine, 2,3,4-trimethoxy-a-methyl-,(S)-
• (S)-1,2,3,4-Tetrahydro-6,7-dimethoxy-1-methyl-2-propylisoquinoline
• Benzenemethanamine, 2-methoxy-alpha,6-dimethyl-, (alphaS)- (9CI)
• 3-(3,4-DIMETHOXY-BENZYLAMINO)-PROPAN-1-OL
• (R)-3-(1-AMINOETHYL)PHENOL HYDROCHLORIDE