DOXACURIUM CHLORIDE
Reaction- Product Name
- DOXACURIUM CHLORIDE
- CAS No.
- 106819-53-8
- Chemical Name
- DOXACURIUM CHLORIDE
- Synonyms
- Nuromax;Doxacurium;BW-A938U;DOXACURIUM CHLORIDE;DOXACURIUM CHLORIDE USP/EP/BP;bis[3-[6,7,8-trimethoxy-2-methyl-1-[(3,4,5-trimethoxyphenyl)methyl]-3,4-dihydro-1h-isoquinolin-2-ium-2-yl]propyl] butanedioate dichloride
- CBNumber
- CB3366932
- Molecular Formula
- C56H78Cl2N2O16
- Formula Weight
- 1106.13
- MOL File
- 106819-53-8.mol
N-Bromosuccinimide Price
- Product number
- D537470
- Product name
- DoxacuriumChloride(MixtureofDiastereomers)
- Packaging
- 25mg
- Price
- $1760
- Updated
- 2021/12/16
- Product number
- API0002483
- Product name
- DOXACURIUM CHLORIDE
- Purity
- 95.00%
- Packaging
- 25G
- Price
- $1503.81
- Updated
- 2021/12/16
DOXACURIUM CHLORIDE Chemical Properties,Usage,Production
Reaction
Ligand for the palladium catalyzed aqueous Lipshutz-Negishi cross-coupling of alkyl halides with aryl electrophiles.
Description
Doxacurium chloride is an injectable, noncumulative, nondepolarizing neuromuscular blocking agent which exhibits no significant cardiovascular effects. It is a mixture of (lR, l′S, 2S, 2′R), (lR, l′R, 2S, 2′s) and (lS, l′S, 2R, 2′R) isomers of a bis-benzylisoquinolinium diester.Doxacurium chloride provides satisfactory intubation with duration of action similar to d-tubocurarine or pancuronium. However, it is reported to be 2 to 3 times as potent as pancuronium.
Originator
Wellcome (United Kingdom)
Uses
Neuromuscular blocking agent.
Uses
Doxacurium Chloride is a nondepolarizing neuromuscular blocking agent that is minimally hydrolyzed by human plasma cholinesterase.
brand name
Nuromax (Abbott).
General Description
The molecular structure of doxacuriumchloride, 1,2,3,4-tetrahydro-2-(3-hydroxypropyl)-6,7,8-trimethoxy2-methyl-1-(3,4,5-trimethoxybenzyl) isoquinoliniumchloride succinate (Nuromax), provides thepossibility for 10 stereoisomers: 4 d,l pairs and two mesoforms. Of the 10 stereoisomers, 3 are all-trans configuration,and these are the only active ones. Doxacurium chlorideis a long-acting nondepolarizing blocking agent. The drugdiffers from drugs such as gallium and pancuronium in thatit has no vagolytic activity. It is used as a skeletal musclerelaxant in surgical procedures expected to last longer than90 minutes.
Pharmacokinetics
Doxacurium is a mixture of three trans, trans-stereoisomers, a dl pair [(1R,1′R,2S,2′S) and (1S,1′S,2R,2′R)] and a meso form (1R,1′S,2S,2′R). Doxacurium is hydrophilic, has a small volume of distribution, and is distributed primarily to extracellular fluids. It is not metabolized by plasma cholinesterase or hepatic enzymes and does not undergo Hofmann elimination.
DOXACURIUM CHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from DOXACURIUM CHLORIDE manufacturers
- Product
- Doxacurium chloride 106819-53-8
- Price
- US $0.00-0.00/Kg
- Min. Order
- 1Kg
- Purity
- 99%；USP/EP/CP
- Supply Ability
- 1-10000kgs
- Release date
- 2023-07-06
- Product
- DOXACURIUM CHLORIDE 106819-53-8
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.9%
- Supply Ability
- 100 Tons min
- Release date
- 2021-08-16
- Product
- Docusate Sodium 106819-53-8
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-06-27