R-tetrahydropapaverine HCl

Product Name: R-tetrahydropapaverine HCl
CAS No.: 54417-53-7
Chemical Name: R-tetrahydropapaverine HCl
Synonyms: R-BINAP;R-Tetrahydropapaverine;R-(+)-Tetrahydropapaverin;R-tetrahydropapaverine HC;R-tetrahydropapaverine HCl;R-TATRAHYDROPAPAVERINE HCL;Atracurium Besylate Impurity 7;D-(-)-Norlaudanosine hydrochloride;Cisatracurium Besilate Impurity 19;(R)-(-)-Norlaudanosine hydrochloride
CBNumber: CB5718052
Molecular Formula: C20H26ClNO4
Formula Weight: 379.88
MOL File: 54417-53-7.mol

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R-tetrahydropapaverine HCl Property

Boiling point:: 475.8℃
Density: 1.32 at 22℃
vapor pressure: 0Pa at 25℃
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: DMSO (Slightly), Methanol (Slightly)
form: Solid
color: White to Off-White
InChI: InChI=1/C20H25NO4.ClH/c1-22-17-6-5-13(10-18(17)23-2)9-16-15-12-20(25-4)19(24-3)11-14(15)7-8-21-16;/h5-6,10-12,16,21H,7-9H2,1-4H3;1H/t16-;/s3
InChIKey: VMPLLPIDRGXFTQ-LSQUZMQTNA-N
SMILES: C(C1C=CC(OC)=C(OC)C=1)[C@H]1NCCC2=CC(OC)=C(OC)C=C12.Cl |&1:11,r|
LogP: -0.63 at 25℃
CAS DataBase Reference: 54417-53-7(CAS DataBase Reference)

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Safety

Hazard Codes: Xn
Risk Statements: 22-52/53
Safety Statements: 22-61

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

AK Scientific

Product number: B660
Product name: R-TetrahydropapaverineHCl
Packaging: 5g
Price: $45
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD132887
Product name: 1-(3,4-Dimethoxybenzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline hydroiodide
Packaging: 10g
Price: $70
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD132887
Product name: 1-(3,4-Dimethoxybenzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline hydroiodide
Packaging: 25g
Price: $145
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 47940
Product name: (R)-(-)-NorlaudanosineHCl
Packaging: 100mg
Price: $635
Updated: 2021/12/16

Crysdot

Product number: CD11107248
Product name: (R)-1-(3,4-Dimethoxybenzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolinehydrochloride
Purity: 97%
Packaging: 1g
Price: $45
Updated: 2021/12/16

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R-tetrahydropapaverine HCl Chemical Properties,Usage,Production

Application

R-tetrahydropapaverine HCl is a useful research chemical.

Synthesis

6429-04-5

54417-53-7

The general procedure for the synthesis of the target compound using 1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride as raw material was as follows: 20 g of 1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride was dissolved in 400 mL of distilled water, and stirred until completely dissolved. Subsequently, ammonia was added to the solution to adjust the pH, and after observing that no white oily material precipitated, 400 mL of toluene was added and mixed with thorough stirring. The organic phase (toluene layer) and the aqueous phase were separated to ensure that there was no residual raw material in the aqueous phase. The organic phase was dried with anhydrous sodium sulfate to obtain 17.3 g of racemate. The racemate was dissolved in 173 mL of acetonitrile and heated to 70 °C. 3.93 g of the splitting agent N-acetyl-D-leucine was slowly added and the reaction was stirred for 20 minutes. Next, 0.522 g of the splitting agent N-acetyl-D-phenylalanine was added and the reaction was continued with stirring for 35 minutes. Upon completion of the reaction, it was slowly cooled to room temperature and subsequently stored in a refrigerator at 4°C for 24 hours to promote crystallization. Upon completion of crystallization, the solid product was collected by filtration. The product was converted to hydrochloride form, treated by adding appropriate amount of hydrochloric acid and dried to give 8.325 g of 1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride in R-configuration. The total yield was 83.25% and the purity was 97.6%.

References

[1] Patent: CN107056700, 2017, A. Location in patent: Paragraph 0040-0043; 0046; 0058

R-tetrahydropapaverine HCl Preparation Products And Raw materials

Raw materials

Preparation Products

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R-tetrahydropapaverine HCl Suppliers

Canada 1 China 211 Germany 3 India 4 United Kingdom 5 United States 9 Global 233

Lianyungang Shenghe Biotechnology Co., Ltd.

Tel: 13585296001 13585296001
Email: haizaofu@163.com
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Shandong Shenghe Pharmaceutical Technology Co. LTD

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Sichuan Mingjian Pharmaceutical Chemical Co., Ltd.

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TIANJIN PHARMACN MEDICAL TECHNOLOGY CO.,LTD.

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J & K SCIENTIFIC LTD.

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Chembest Research Laboratories Limited

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Wuhan Chemwish Technology Co., Ltd

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Shanghai Sinch Parmaceuticals Tech. Co. Ltd.

Tel: +86-21-54098501
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Jia Xing Isenchem Co.,Ltd

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View Lastest Price from R-tetrahydropapaverine HCl manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: R-tetrahydropapaverine HCl 54417-53-7
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1KG 10KG 100KG
Release date: 2025-05-22

Shaanxi Dideu New Materials Co. Ltd

Product: R-tetrahydropapaverine HCl 54417-53-7
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10000KGS
Release date: 2025-03-06

R&D Scientific Inc.

Product: R-tetrahydropapaverine HCl 54417-53-7
Price: US $890.00/Kg
Min. Order: 1Kg
Purity: 98
Supply Ability: 500 Kg
Release date: 2024-05-07

54417-53-7, R-tetrahydropapaverine HClRelated Search:

(1R,1'R,2S,2'S)-2,2'-[1,5-pentanediylbis[oxy(3-oxo-3,1-propanediyl)]]bis[1-[(3,4-dimethoxyphenyl)methyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-Isoquinolinium Benzenesulfonate BOLDINE DIMETHYL ETHER Tetrahydrofuran Tetramethylammonium hydroxide pentahydrate Papaverine hydrochloride 1-[(3,4-Dimethoxyphenyl)methyl]-3,4-dihydro-6,7-dimethoxyisoquinoline cis-1,2,3,6-Tetrahydrophthalic anhydride Tetrahydrothiophene Atracurium besylate PHENYL P-TOLYL SULFONE AtracuriuM IMpurity A1 (trans-Monoquatenary) Atracurium Impurity 34 Iodide Atracurium Impurity 12 Iodide (Mixture of Diastereomers) Atracurium Impurity 24 Atracurium Impurity 1 Atracurium Impurity 32 Atracurium Impurity 19 1,5-pentanediyl bis[1-[(3,4-dimethoxyphenyl)methyl]-3,4-dihydro-6,7-dimethoxy-1H-isoquinoline-2-propionate]

R-tetrahydropapaverine HCl

R-(+)-TETRAHYDROPAPAVERIN HYDROCHLORIDE

(r)-1,2,3,4-tetrahydro-6,7-dimethoxy-1-veratrylisoquinoline

(R)-1-(3,4-DIMETHOXY-BENZYL)-6,7-DIMETHOXY-1,2,3,4-TETRAHYDRO-ISOQUINOLINE HYDROCHLORIDE

R-(+)-Tetrahydropapaverin

(R)-1-(3,4-DIMETHOXY-BENZYL)-6,7-DIMETHOXY-1,2,3,4-TETRAHYDRO-ISOQUINOLINE HYDROCHLORID

R-Tetrahydropapaverine

R-BINAP

Atracurium Impurity 7 (R-Tetrahydropapaverine)

(R)-1,2,3,4-tetrahydro-6,7-dimethoxy-1-veratrylisoquinoline hydrochloride

Isoquinoline, 1-[(3,4-dimethoxyphenyl)methyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-, hydrochloride (1:1), (1R)-

http://www.gabrielpharm.com/hy/detailpro.phpid=39

D-(-)-Norlaudanosine hydrochloride

(1R)-1-[(3,4-diMethoxyphenyl)Methyl]-6,7-diMethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride

(R)-1-(3,4-DIMETHOXY-BENZYL)-6,7-DIMETHOXY-1,2,3,4-TETRAHYDRO-ISOQUINOLINE HCL

R-TATRAHYDROPAPAVERINE HCL

(R)-(-)-Norlaudanosine hydrochloride

1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline hydroiodide

Atracurium Impurity 7(R-Tetrahydropapaverine HCl)

Atracurium Besylate Impurity 7

(1R,2R)-1-(3,4-dimethoxybenzyl)-2-(3-ethoxy-3-oxopropyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-2-ium benzenesulfonate

Cisatracurium Besilate Impurity 19

(R)-tetrahydropapaverine hydrochloride salt

R-tetrahydropapaverine HC

R-TETRA HYDRO PEPAVERINE HYDROCHLORIDE

(R)-TetrahydroberberineHydrochloride

54417-53-7

Analgesic series