DOXACURIUM CHLORIDE

Reaction

Product Name: DOXACURIUM CHLORIDE
CAS No.: 106819-53-8
Chemical Name: DOXACURIUM CHLORIDE
Synonyms: Nuromax;Doxacurium;BW-A938U;DOXACURIUM CHLORIDE;DOXACURIUM CHLORIDE USP/EP/BP;bis[3-[6,7,8-trimethoxy-2-methyl-1-[(3,4,5-trimethoxyphenyl)methyl]-3,4-dihydro-1h-isoquinolin-2-ium-2-yl]propyl] butanedioate dichloride
CBNumber: CB3366932
Molecular Formula: C56H78Cl2N2O16
Formula Weight: 1106.13
MOL File: 106819-53-8.mol

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DOXACURIUM CHLORIDE Property

InChIKey: APADFLLAXHIMFU-QBTMMFGGNA-L

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: D537470
Product name: DoxacuriumChloride(MixtureofDiastereomers)
Packaging: 25mg
Price: $1760
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0002483
Product name: DOXACURIUM CHLORIDE
Purity: 95.00%
Packaging: 25G
Price: $1503.81
Updated: 2021/12/16

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DOXACURIUM CHLORIDE Chemical Properties,Usage,Production

Reaction

Ligand for the palladium catalyzed aqueous Lipshutz-Negishi cross-coupling of alkyl halides with aryl electrophiles.

Description

Doxacurium chloride is an injectable, noncumulative, nondepolarizing neuromuscular blocking agent which exhibits no significant cardiovascular effects. It is a mixture of (lR, l′S, 2S, 2′R), (lR, l′R, 2S, 2′s) and (lS, l′S, 2R, 2′R) isomers of a bis-benzylisoquinolinium diester.Doxacurium chloride provides satisfactory intubation with duration of action similar to d-tubocurarine or pancuronium. However, it is reported to be 2 to 3 times as potent as pancuronium.

Chemical Properties

Amorphous solid. Soluble in water.

Originator

Wellcome (United Kingdom)

Uses

Neuromuscular blocking agent.

Uses

Doxacurium Chloride is a nondepolarizing neuromuscular blocking agent that is minimally hydrolyzed by human plasma cholinesterase.

brand name

Nuromax (Abbott).

General Description

The molecular structure of doxacuriumchloride, 1,2,3,4-tetrahydro-2-(3-hydroxypropyl)-6,7,8-trimethoxy2-methyl-1-(3,4,5-trimethoxybenzyl) isoquinoliniumchloride succinate (Nuromax), provides thepossibility for 10 stereoisomers: 4 d,l pairs and two mesoforms. Of the 10 stereoisomers, 3 are all-trans configuration,and these are the only active ones. Doxacurium chlorideis a long-acting nondepolarizing blocking agent. The drugdiffers from drugs such as gallium and pancuronium in thatit has no vagolytic activity. It is used as a skeletal musclerelaxant in surgical procedures expected to last longer than90 minutes.

Pharmacokinetics

Doxacurium is a mixture of three trans, trans-stereoisomers, a dl pair [(1R,1′R,2S,2′S) and (1S,1′S,2R,2′R)] and a meso form (1R,1′S,2S,2′R). Doxacurium is hydrophilic, has a small volume of distribution, and is distributed primarily to extracellular fluids. It is not metabolized by plasma cholinesterase or hepatic enzymes and does not undergo Hofmann elimination.

DOXACURIUM CHLORIDE Preparation Products And Raw materials

Raw materials

DoxacuriumChloride PAPAVERINE 3-Iodopropanol SUCCINYL CHLORIDE

Preparation Products

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DOXACURIUM CHLORIDE Suppliers

China 28 Europe 2 India 2 United States 6 Global 38

Hubei jian chu biological technology co., LTD

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View Lastest Price from DOXACURIUM CHLORIDE manufacturers

Changzhou Rokechem Technology Co., Ltd.

Product: Doxacurium chloride 106819-53-8
Price: US $0.00-0.00/Kg
Min. Order: 1Kg
Purity: 99%；USP/EP/CP
Supply Ability: 1-10000kgs
Release date: 2023-07-06

Dideu Industries Group Limited

Product: DOXACURIUM CHLORIDE 106819-53-8
Price: US $1.10/g
Min. Order: 1g
Purity: 99.9%
Supply Ability: 100 Tons min
Release date: 2021-08-16

Zhuozhou Wenxi import and Export Co., Ltd

Product: Docusate Sodium 106819-53-8
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-06-27

106819-53-8, DOXACURIUM CHLORIDERelated Search:

2,4-Dimethoxybenzylamine hydrochloride (S)-1-(2-Methoxyphenyl)ethylamine (+/-)-Tetrahydropapaverine 1,4-BUTANEDIOL BIS(3-AMINOPROPYL) ETHER R-tetrahydropapaverine HCl Tetrahydropapaverine hydrochloride PHENOL, 2-METHOXY-5-[2-(3,4,5-TRIMETHOXYPHENYL)ETHYL]- (R)-1-(2-Methoxyphenyl)ethylamine (R)-1-(3-Methoxyphenyl)ethylamine Trimethoxyamphetamine 5'-Methoxylaudanosine DOXACURIUM CHLORIDE 3,4,5-TRIMETHOXYPHENETHYLAMINE, HYDROCHLORIDE Benzenemethanamine, 2,3,4-trimethoxy-a-methyl-,(S)- (S)-1,2,3,4-Tetrahydro-6,7-dimethoxy-1-methyl-2-propylisoquinoline Benzenemethanamine, 2-methoxy-alpha,6-dimethyl-, (alphaS)- (9CI) 3-(3,4-DIMETHOXY-BENZYLAMINO)-PROPAN-1-OL (R)-3-(1-AMINOETHYL)PHENOL HYDROCHLORIDE

DOXACURIUM CHLORIDE

Doxacurium

BW-A938U

Nuromax

bis[3-[6,7,8-trimethoxy-2-methyl-1-[(3,4,5-trimethoxyphenyl)methyl]-3,4-dihydro-1h-isoquinolin-2-ium-2-yl]propyl] butanedioate dichloride

DOXACURIUM CHLORIDE USP/EP/BP

106819-53-8

C56H78Cl2N2O16