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NUARIMOL

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NUARIMOL Basic information

Product Name:
NUARIMOL
Synonyms:
  • 2-CHLORO-4'-FLUORO-A-(PYRIMIDIN-5-YL)BENZ HYDROXYLALCOHOL
  • (2-CHLOROPHENYL)-(4-FLUOROPHENYL)-PYRIMIDIN-5-YL-METHANOL
  • NUARIMOL
  • TRIMIDAL
  • (+-)-2-chloro-4’-fluoro-alpha-(pyrimidin-5-yl)benzhydrylalcohol
  • murox
  • trimifruitsc
  • triminol
CAS:
63284-71-9
MF:
C17H12ClFN2O
MW:
314.74
EINECS:
264-071-1
Product Categories:
  • NJ - NZPesticides
  • Alpha sort
  • Fungicides
  • N
  • N-PAlphabetic
  • Pesticides&Metabolites
  • Pyrimidines
Mol File:
63284-71-9.mol
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NUARIMOL Chemical Properties

Melting point:
126°C
Boiling point:
475.2±40.0 °C(Predicted)
Density 
1.3255 (estimate)
vapor pressure 
1 x 10-5 Pa at 23 °C
storage temp. 
0-6°C
solubility 
Chloroform (Slightly), Methanol (Slightly)
pka
11.37±0.29(Predicted)
Water Solubility 
26 mg l-1 (pH 7) at 25 °C
color 
White to Pale Yellow
BRN 
6223667
EPA Substance Registry System
Nuarimol (63284-71-9)
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Safety Information

Hazard Codes 
Xn
Risk Statements 
22-36
Safety Statements 
26
WGK Germany 
3
RTECS 
UV9279700
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NUARIMOL Usage And Synthesis

Uses

Nuarimol is a systemic fungicide with both curative and protective activity. It controls a wide range of pathogenic fungi, e.g. Cercosporella spp., Septoria spp., Ustilago spp., powdery mildews, leaf spot, etc. in cereals (as a foliar spray and as a seed treatment), powdery mildews on pome fruits, stone fruits, vines, cucurbits and other crops and scab on apples.

Uses

Nuarimol is used in the preparation of difluoroethyl-containing heterocyclic compounds useful as antiviral agents and fungicides. Also used as a substance in the modelling inhibition of avian aromatase by azole pesticides.

Metabolic pathway

Photolytic degradation is the primary dissipation mechanism of nuarimol in the environment. Major degradation reactions observed on plants/soil surfaces and water include hydroxylation of the phenyl groups, oxidation of the carbinol carbon atom, dehalogenation and carbinol dehydroxylation (Scheme 1). The primary metabolic pathway of nuarimol in rats involves mainly aryl hydroxylation (Scheme 2).

Degradation

Nuarimol is stable to hydrolytic degradation when maintained in sterile buffered solutions (pH 3,6 and 9) in the dark at 52 °C (Saunders, 1977). It was readily degraded in distilled water via photolysis. The photolytic DT50 of nuarimol was approximately 1 hour. Numerous photoproducts were observed; however, no structural characterisation information was reported (Zornes and Donoho, 1978).
Nuarimol was extensively photodegraded on solid surfaces. More than 80 photodegradation products were observed when nuarimol was exposed to sunlight on a stainless steel surface for up to 150 hours (Althaus, 1980a). All photoproducts were formed at very low levels (less than 3% each). The structures of 23 photoproducts were identified. An abbreviated photodegradation pathway of nuarimol (based on products accounting for 1% or greater) is presented in Scheme 1. These products were generated from the following reactions: aryl hydroxylation of the chlorophenyl and fluorophenyl moieties (to yield 2, 3), cleavage of the pyrimidine ring and the oxidation of the carbinol carbon atom (4,5) and dehydroxylation of the carbinol moiety (6). Carboxylic acid fragments from the phenyl(7,8,9) and pyrimidine moieties (10), resulting from the cleavage of the parent phenyl and pyrimidine linkages, were also observed.

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