ANTI-MTA2 Chemical Properties

storage temp. 

−20°C

form 

buffered aqueous solution

biological source

rabbit

Safety Information

WGK Germany 

-

Storage Class

10 - Combustible liquids

MSDS

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ANTI-MTA2 Usage And Synthesis

Uses

Monoclonal Anti-MTA2 antibody produced in mouse has been used in:

• enzyme linked immunosorbent assay (ELISA)
• immunoprecipitation
• immunocytochemistry
• Western blotting
• antibody microarray

Biological Activity

MTA2 may be involved in the regulation of gene expression as repressor and activator. The repression might be related to covalent modification of histone proteins.This gene encodes a protein th at has been identified as a component of NuRD, a nucleosome remodeling deacetylase complex identified in the nucleus of human cells. It shows a very broad expression pattern and is strongly expressed in many tissues. It may represent one member of a small gene family th at encode different but related proteins involved either directly or indirectly in transcriptional regulation. Their indirect effects on transcriptional regulation may include chromatin remodeling. It is closely related to another member of this family, a protein th at has been correlated with the metastatic potential of certain carcinomas. These two proteins are so closely related th at they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins th at methylate DNA. One of the proteins known to be a target protein for this gene product is p53. Deacteylation of p53 is correlated with a loss of growth inhibition in transformed cells supporting a connection between these gene family members and metastasis. Publication Note: This RefSeq record includes a subset of the publications th at are available for this gene. Please see the Entrez Gene record to access additional publications.