2-Methoxyethyl 2-[(3-nitrophenyl)methylene]acetoacetate Chemical Properties

Melting point:

72-74°C

Boiling point:

433.4±40.0 °C(Predicted)

Density 

1.266±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,2-8°C

solubility 

DMSO, Methanol

form 

Solid

color 

Off-White to Pale Yellow

CAS DataBase Reference

39562-22-6(CAS DataBase Reference)

Safety Information

HazardClass 

IRRITANT

2-Methoxyethyl 2-[(3-nitrophenyl)methylene]acetoacetate Usage And Synthesis

Chemical Properties

Off-White to Pale Yellow Solid

Uses

Cilnidipine intermediate.

Hazard

Low toxicity by ingestion and inhalation. A moderate eye irritant.

Synthesis

200 kg of methoxyethyl acetoacetate and 185.1 kg of 3-nitrobenzaldehyde were suspended in 800 l of isopropanol. Then 5.65 kg of p-anisic acid and 5.05 kg of an ethanol solution of 33% dimethylamine were added and heated at about 35??C for about 30 minutes to obtain a solution. The reaction mixture was cooled to 20/25??C, then it was cooled with running water for about 12 hours and cooled with brine at about 0??C for another 24 hours, then centrifuged and washed with isopropanol. After drying, 327 kg of 3-nitrophenylforkylacetoacetic acid methoxyethyl ester was obtained in about 91% yield.

2-Methoxyethyl 2-[(3-nitrophenyl)methylene]acetoacetate(39562-22-6)Related Product Information

• Linezolid
• Acetic acid
• 2-(2-Nitrobenzylidene)-3-oxobutanoic Acid, 2-Acetoxy-2-methylpropyl Ester
• 2-Methoxyethyl acetoacetate
• 2-Methoxyethyl 2-[(3-nitrophenyl)methylene]acetoacetate
• ALPHA-ETHYL-3-NITROCINNAMIC ACID
• ETHYL 3-AMINOCINNAMATE
• ETHYL 3-NITROCINNAMATE