1-TERT-BUTOXYCARBONYLAMINO-CYCLOHEXANECARBOXYLIC ACID Chemical Properties

Melting point:

176-178 °C (dec.)

storage temp. 

Sealed in dry,Room Temperature

form 

solid

color 

White

BRN 

4189683

Major Application

peptide synthesis

InChI

1S/C12H21NO4/c1-11(2,3)17-10(16)13-12(9(14)15)7-5-4-6-8-12/h4-8H2,1-3H3,(H,13,16)(H,14,15)

InChIKey

URBHKVWOYIMKNO-UHFFFAOYSA-N

SMILES

CC(C)(C)OC(=O)NC1(CCCCC1)C(O)=O

CAS DataBase Reference

115951-16-1(CAS DataBase Reference)

Safety Information

WGK Germany 

3

HazardClass 

IRRITANT

HS Code 

29225090

Storage Class

13 - Non Combustible Solids

MSDS

• Language:English Provider:SigmaAldrich

1-TERT-BUTOXYCARBONYLAMINO-CYCLOHEXANECARBOXYLIC ACID Usage And Synthesis

Chemical Properties

White powder

Uses

peptide synthesis

reaction suitability

reaction type: Boc solid-phase peptide synthesis

Synthesis

1-tert-butoxycarbonylamide cyclohexanecarboxylic acid was prepared as follows: sodium hydroxide solution (43 mL, 4 mol/L), THF (40 mL) and 1-aminocyclohexanecarboxylic acid (5.0 g, 34.96 mmol) were added to a round-bottomed flask, and di-tert-butyl dicarbonate (9.13 g, 41.96 mmol) was added to the reaction flask at 0 ??C. After dropwise addition was complete, the reaction system was After the dropwise addition, the reaction system was stirred at room temperature overnight. Water (100 mL) was added to the reaction system, acidified with hydrochloric acid (50 mL, 1 mol/L), then extracted with ethyl acetate (50 mL??2), the organic phases were combined, and the organic phases were washed with saturated brine (100 mL??2) and dried with anhydrous sodium sulfate. Filtered, evaporated the solvent under reduced pressure, the crude product was purified by silica gel column chromatography (petroleum ether/ethyl acetate (V/V) = 4/1) to give the white solid title compound 1-tert-butoxycarbonylamide cyclohexanecarboxylic acid (7.3 g, 86%).

1-TERT-BUTOXYCARBONYLAMINO-CYCLOHEXANECARBOXYLIC ACID(115951-16-1)Related Product Information

• 1-TERT-BUTOXYCARBONYLAMINO-CYCLOHEXANECARBOXYLIC ACID
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• BOC-CIS-1,4-AMINO-1-CYCLOHEXANE CARBOXYLIC ACID
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