tert-butyl 4-(7-bromo-6-chloro-8-fluoroquinazolin-4-yl)piperazine-1-carboxylate
tert-butyl 4-(7-bromo-6-chloro-8-fluoroquinazolin-4-yl)piperazine-1-carboxylate Basic information
- Product Name:
- tert-butyl 4-(7-bromo-6-chloro-8-fluoroquinazolin-4-yl)piperazine-1-carboxylate
- Synonyms:
-
- 1588-A4
- tert-butyl 4-(7-bromo-6-chloro-8-fluoroquinazolin-4-yl)piperazine-1-carboxylate
- 1-Piperazinecarboxylic acid, 4-(7-bromo-6-chloro-8-fluoro-4-quinazolinyl)-, 1,1-dimethylethyl ester
- ARS-1620 Intermediate
- 1588-A-4,1588A4,1588 A4
- CAS:
- 1698027-20-1
- MF:
- C17H19BrClFN4O2
- MW:
- 445.71
- Mol File:
- 1698027-20-1.mol
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tert-butyl 4-(7-bromo-6-chloro-8-fluoroquinazolin-4-yl)piperazine-1-carboxylate Chemical Properties
- Boiling point:
- 534.9±50.0 °C(Predicted)
- Density
- 1.521±0.06 g/cm3(Predicted)
- solubility
- DMSO: Slightly soluble: 0.1-1 mg/ml
- pka
- 10.06±0.70(Predicted)
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tert-butyl 4-(7-bromo-6-chloro-8-fluoroquinazolin-4-yl)piperazine-1-carboxylate Usage And Synthesis
Description
1588-A4 is a synthetic intermediate that has been used in the synthesis of the K-RasG12C inhibitor ARS1620 (Item No. 27915).1 WARNING This product is not for human or veterinary use.
References
[1] MATTHEW R JANES. Targeting KRAS Mutant Cancers with a Covalent G12C-Specific Inhibitor.[J]. Cell, 2018, 172 3: 578-589.e17. DOI: 10.1016/j.cell.2018.01.006
tert-butyl 4-(7-bromo-6-chloro-8-fluoroquinazolin-4-yl)piperazine-1-carboxylateSupplier
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