GLP-2 (HUMAN) TRIFLUOROACETATE SALT Chemical Properties

storage temp. 

-15°C

solubility 

Formic Acid: 1 mg/ml

GLP-2 (HUMAN) TRIFLUOROACETATE SALT Usage And Synthesis

Description

Glucagon-like peptide-2 (GLP-2) is an endogenous peptide hormone formed in L cells of the small and large intestine by cleavage of proglucagon in response to nutrient ingestion. In vivo, GLP-2 (43.75 μg twice a day) increases crypt cell proliferation, total weight of the small bowel, and mucosal thickness of the proximal and distal jejunum and ileum in mice. It increases jejunal mucosal surface area and reduces resection-induced decreases in SGLT-1 and GLUT-2 transporter abundance, as well as resection-induced increases in blood glucose levels and body fat loss, in a rat model of distal bowel resection. GLP-2 also increases intrahepatic lipid concentration, hepatic steatosis, and plasma concentrations of cholesterol and triglycerides in mice fed a high-fat diet but has no effect on mice fed a standard diet.

References

[1] D J DRUCKER. Induction of intestinal epithelial proliferation by glucagon-like peptide 2.[J]. Proceedings of the National Academy of Sciences of the United States of America, 1996, 93 15: 7911-7916. DOI: 10.1073/pnas.93.15.7911
[2] S. BALDASSANO. Influence of endogenous glucagon-like peptide-2 on lipid disorders in mice fed a high-fat diet[J]. Endocrine Research, 2016, 41 1: 317-324. DOI: 10.3109/07435800.2016.1141950
[3] SARAH W LAI. Effects of exogenous glucagon-like peptide-2 and distal bowel resection on intestinal and systemic adaptive responses in rats.[J]. PLoS ONE, 2017: e0181453. DOI: 10.1371/journal.pone.0181453

GLP-2 (HUMAN) TRIFLUOROACETATE SALT()Related Product Information

• GLP-2 (HUMAN)
• GLP-2 (HUMAN)