D-VAL-PHE-LYS CHLOROMETHYL KETONE, DIHYDROCHLORIDE Chemical Properties

Boiling point:

707.0±60.0 °C(Predicted)

Density 

1.160±0.06 g/cm3(Predicted)

storage temp. 

2-8°C

solubility 

DMSO: 5mg/mL

pka

13.06±0.46(Predicted)

form 

lyophilized solid

color 

off-white

Sequence

{d-Val}-Phe-Lys-{CMK}

D-VAL-PHE-LYS CHLOROMETHYL KETONE, DIHYDROCHLORIDE Usage And Synthesis

Uses

D-Val-Phe-Lys-CMK (D-Val-Phe-Lys Chloromethyl ketone) can inhibit plasmin activity[1].

Biological Activity

Cell permeable: no', 'Primary Target
Human plasmin', 'Product does not compete with ATP.', 'Reversible: no', 'Target IC50: 100 pM for human plasmin

References

[1] F Laube, et al. Cell surface antigens in renal tumour cells: detection by immunoluminescence and enzymatic analysis. Br J Cancer. 2001 Sep 14;85(6):924-9. DOI:10.1054/bjoc.2001.2004

D-VAL-PHE-LYS CHLOROMETHYL KETONE, DIHYDROCHLORIDE(75590-17-9)Related Product Information

• PLASMIN
• (R)-(+)-1,2-Diaminopropane dihydrochloride
• H-D-ALA-GLY-NH2 HCL
• N-(1-methyl-2-oxopropyl)acetamide
• D-VAL-PHE-LYS CHLOROMETHYL KETONE, DIHYDROCHLORIDE
• (R)-(-)-2-AMINOBUTANAMIDE HYDROCHLORIDE, 97%
• H-GLY-PHE-NH2 HCL
• N-METHYL-3-CHLOROPROPYLAMINE HYDROCHLORIDE
• (2R)-2-Aminopropanamide hydrochloride
• H-D-VAL-NH2 HCL