Basic information Description References Safety Supplier Related
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Tamsulosin hydrochloride

Basic information Description References Safety Supplier Related

Tamsulosin hydrochloride Basic information

Product Name:
Tamsulosin hydrochloride
Synonyms:
  • (R)-(-)-5-[2-[2-(2-Ethoxyphenoxy)ethylamino]propyl]-2-methoxybenzolsulfonamid hydrochloride
  • 5-[(2R)-2-[[2-(2-Ethoxyphenoxy)ethyl]amino]propyl]-2-benzenesulfonamidehydrochloride
  • Flomax hydrochloride
  • TaMsulosin Hydrochloride, EP
  • Tamsulosin Hydrochloride (200 mg)
  • 5-[(R)-2-[2-(2-Ethoxyphenoxy)ethylamino]propyl]]-2-methoxybenzenesulfonamide Hydrochloride
  • (S)-5-(2-((2-(2-ethoxyphenoxy)ethyl)aMino)propyl)-2-MethoxybenzenesulfonaMide
  • TAMSULOSIN HYDRCHLORIDE
CAS:
106463-17-6
MF:
C20H29ClN2O5S
MW:
444.97
EINECS:
629-756-5
Product Categories:
  • Tamsulosin
  • Adrenoceptor
  • MUSTARDGEN
  • Isotope Labelled Compounds
  • Isotope Labeled Compounds
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Chiral Reagents
  • In treatment of benign prostatic hypertrophy
  • Treatment of BPH
  • Active Pharmaceutical Ingredients
  • API
Mol File:
106463-17-6.mol
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Tamsulosin hydrochloride Chemical Properties

Melting point:
228-230°C
alpha 
D24 -4.0° (c = 0.35 in methanol)
RTECS 
DB2430000
storage temp. 
Desiccate at RT
solubility 
DMSO: >10mg/mL
form 
white powder
Merck 
14,9049
InChIKey
ZZIZZTHXZRDOFM-XFULWGLBSA-N
CAS DataBase Reference
106463-17-6(CAS DataBase Reference)
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Safety Information

Hazard Codes 
Xn
Risk Statements 
22-36/37/38
Safety Statements 
26
WGK Germany 
3
HS Code 
29350090
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Tamsulosin hydrochloride Usage And Synthesis

Description

Tamsulosin hydrochloride is the hydrochloride form of Tamsulosin (Trade name: Alna ® / Flomax ®). It is a kind of medication used for the treatment of symptomatic benign prostatic hyperplasia (BPH), boosting the passage of kidney stones. It can also be used for the treatment of acute urinary retention. It is a kind of selective antagonist of alpha-1A and alpha-1B-adrenoceptros located in prostate, prostatic capsule, prostatic urethra, and bladder neck. The blockage of these receptors through Tamsulosin causes the relaxation of smooth muscles in the bladder neck and prostate.

References

https://www.drugbank.ca/drugs/DB00706
https://en.wikipedia.org/wiki/Tamsulosin

Chemical Properties

White to Off-White Solid

Originator

Contiflo OD,Ranbaxy Laboratories,India

Uses

Specific a1-adrenoceptor antagonist. Used in the treatment of benign prostatic hypertrophy

Uses

Specific α1-adrenoceptor antagonist. Used in the treatment of benign prostatic hypertrophy.

Uses

antineoplastic, alkylating agent

Uses

(R)-Tamsulosin is a specific α1-adrenoceptor antagonist. It is used in the treatment of benign prostatic hypertrophy.

Uses

An α1-adrenoceptor antagonist

Manufacturing Process

In 1,000 ml of acetonitrile was suspended 17 g of 5-{2-[2-(2- ethoxyphenoxy)ethylamino]-1-hydroxy-2-methylethyl}-2- methoxybenzenesulfonamide hydrochloride and while stirring the suspension, 9 g of thionyl chloride was added dropwise to the suspension at room temperature, whereby the product first dissolved and then began to crystallize gradually. After stirring the mixture for two days, the crystals formed were recovered by filtration, washed with chloroform and dried to provide 15 g of 5-{1-chloro-2-[2-(2-ethoxyphenoxy)ethylamino]-2-methylethyl}-2- methoxybenzenesulfonamide hydrochloride. Melting point: 197°-200°C.
In methanol was dissolved the 5-{1-chloro-2-[2-(2- ethoxyphenoxy)ethylamino]ethyl}-2-methoxybenzenesulfonamide hydrochloride and after adding thereto 10% palladium carbon, dechlorination was performed under hydrogen stream at normal temperature and pressure. The palladium carbon was filtered away and the filtrate was concentrated under reduced pressure to provide the 2-methoxy-5-{2-[2-(2- ethoxyphenoxy)ethylamino]ethyl}benzenesulfonamide hydrochloride, which was recrystallized from 120 ml of a mixture of methanol and ethanol (1:4 by volume ratio) to provide the colorless crystals thereof. The melting point of the 5-{2-[2-(2-ethoxyphenoxy)ethylamino]-2-methylethyl}-2- methoxybenzenesulfonamide hydrochloride: 254°-256°C.

Therapeutic Function

Antihypertensive

Hazard

Moderately toxic by ingestion.

Biological Activity

Selective α 1A -adrenoceptor antagonist (pK i values are 9.97, 9.64 and 8.86 for α 1A , α 1B and α 1D subtypes respectively). Decreases resting maximal urethral pressure with negligable effect on mean arterial blood pressure in vivo .

Tamsulosin hydrochloride Supplier

Guangzhou Tonghui Pharmaceutical Co., Ltd. Gold
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020-66392416
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Shanghai Zhen Li Biological Technology Co., Ltd Gold
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1304-5646768- ; ;
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Shanghai Botuo Biotechnology Co., LTD Gold
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J & K SCIENTIFIC LTD.
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Meryer (Shanghai) Chemical Technology Co., Ltd.
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21-61259100-
Email
sh@meryer.com