N-OMEGA-PROPYL-L-ARGININE Chemical Properties

Melting point:

198-200?C

Boiling point:

366.5±52.0 °C(Predicted)

Density 

1.24±0.1 g/cm3(Predicted)

storage temp. 

Desiccate at RT

solubility 

Chloroform (Slightly), Methanol (Slightly)

pka

2.50±0.24(Predicted)

form 

White to off-white solid.

color 

White

Stability:

Very Hygroscopic

CAS DataBase Reference

137361-05-8(CAS DataBase Reference)

N-OMEGA-PROPYL-L-ARGININE Usage And Synthesis

Description

N^ω-Propyl-L-Arginine is a potent and selective inhibitor of neuronal nitric oxide synthase (nNOS). N^ω-Propyl-L-Arginine is a competitive inhibitor of bovine nNOS having a K_i value of 57 nM. The K_i values for eNOS (bovine) and iNOS (murine) are 8.5 and 180 μM, respectively. N^ω-propyl-L-Arginine therefore exhibits 3,000-fold and 150-fold selectivity for the neuronal isoform versus the inducible (murine) and endothelial (bovine) isoforms of NOS, respectively.

Chemical Properties

Off-White Solid

Uses

Nω-Propyl-L-Arginine is a neuronal selective nitric oxide synthase inhibitor (1) and a highly selective competitive inhibitor and inactivator of all three isoforms of NOS (2,3).

Uses

A highly selective competitive inhibitor and inactivator of all three isoforms of NOS.

Biological Activity

Highly selective and potent inhibitor of nNOS (K i = 57 nM). Displays 3158-fold and 149-fold selectivity over iNOS and eNOS respectively. Hypotensive in vivo .

storage

room temperature (desiccate)

N-OMEGA-PROPYL-L-ARGININE(137361-05-8)Related Product Information

• N-ACETYLLACTOSAMINE
• Dodecyl acrylate
• L-Ornithine
• Nomega-Propyl-L-arginine
• BRADYKININ DIACETATE HEPTAHYDRATE
• ARGININOSUCCINIC ACID DISODIUM SALT