OXYTHIAMINE HYDROCHLORIDE
OXYTHIAMINE HYDROCHLORIDE Basic information
- Product Name:
- OXYTHIAMINE HYDROCHLORIDE
- Synonyms:
-
- 5-(2-HYDROXYETHYL)-3-(4-HYDROXY-2-METHYL-5-PYRIMIDINYLMETHYL)-4-METHYLTHIAZOLIUM CHLORIDE
- 5-[2-HYDROXYETHYL]-3-[4-HYDROXY-2-METHYL-5-PYRIMIDINYLMETHYL]-4-METHYLTHIAZOLIUM CHLORIDE HYDROCHLORIDE
- Oxametholone Hydrochloride
- hydroxythiaminechloridehydrochloride
- hyl)-4-methyl-,chloride,monohydrochloride
- OXYTHIAMINE CHLORIDE HYDROCHLORIDE
- OXYTHIAMINE HCL
- OXYTHIAMINE HYDROCHLORIDE
- CAS:
- 614-05-1
- MF:
- C12H17Cl2N3O2S
- MW:
- 338.25
- Product Categories:
-
- Biochemistry
- Vitamin Derivatives
- Vitamins
- Mol File:
- 614-05-1.mol
OXYTHIAMINE HYDROCHLORIDE Chemical Properties
- Melting point:
- >190°C (subl.)
- storage temp.
- -20°C
- solubility
- DMSO (Slightly, Heated), Methanol (Slightly), Water (Slightly)
- form
- Solid
- color
- White to Off-White
- Stability:
- Hygroscopic
MSDS
- Language:English Provider:SigmaAldrich
OXYTHIAMINE HYDROCHLORIDE Usage And Synthesis
Uses
thiamine antagonist
Uses
Oxythiamine chloride hydrochloride is suitable for use:
- as a reference standard for calibration curve generation in liquid chromatography-tandem mass spectrometry (LC-MS/MS) for oxythiamine pyrophosphate (OTPP) quantification in red blood cells
- as a thiamine transport inhibitor in human mammary epithelial cells (HMEC) and breast cancer cell lines
- in the synthesis of oxythiamineH picrolonate salt
Definition
ChEBI: A hydrochloride obtained by combining oxythiamine chloride with one molar equivalent of hydrochloric acid.
General Description
Oxythiamine is a thiamine antimetabolite and the source through diet is by consuming acidic thiamine rich foods.
Biochem/physiol Actions
Oxythiamine (OT) is a thiamine antagonist. It is a transketolase inhibitor and is employed to study anti-metastatic mechanisms, especially those involving metalloproteinases (MMP). It significantly sensitizes human hepatocellular carcinoma cells (HCC) to sorafenib, favoring tumor suppression.
in vivo
Oxythiamine chloride hydrochloride (100-500 mg/kg, i.p. 4 days) inhibits tumor growth in Ehrlich's ascites tumor hosting mice[2].
Oxythiamine chloride hydrochloride (250 or 500 mg/kg, daily for 5 week) inhibits tumor cell metastasis via inhibition of MMPs in mice implanted (s.c.) with LLC cells[4].
| Animal Model: | Ehrlich's ascites tumor hosting mice[2] |
| Dosage: | 100-500 mg/kg |
| Administration: | i.p., 4 days |
| Result: | Inhibited tumor growth by 43% at 300 mg/kg and 84% at 500 mg/kg. |
OXYTHIAMINE HYDROCHLORIDESupplier
- Tel
- 18210857532; 18210857532
- jkinfo@jkchemical.com
- Tel
- 4006356688 18621169109
- market03@meryer.com
- Tel
- 021-58099652-8005 13585536065
- bin.wu@shlschem.com
- Tel
- 021-50135380
- shchemsky@sina.com
- Tel
- 4009903999 13355009207
- 3007715519@qq.com