7-(PIPERIDIN-1-YLMETHYL)QUINOLIN-8-OL Chemical Properties

Melting point:

194 °C

Boiling point:

402.4±30.0 °C(Predicted)

Density 

1.202±0.06 g/cm3(Predicted)

storage temp. 

2-8°C

solubility 

DMSO: 5mg/mL, clear (warmed)

pka

3.81±0.50(Predicted)

form 

powder

color 

white to beige

7-(PIPERIDIN-1-YLMETHYL)QUINOLIN-8-OL Usage And Synthesis

Uses

NSC-57969 is a multidrug resistant (MDR)-selective agent, exhibiting a robust Pgp-dependent toxic activity across diverse cancer cell lines[1].

Biological Activity

NSC57969 is a MDR-selective compound th at exhibits a robust Pgp-dependent toxic activity across diverse cancer cell lines. NSC57969 shows profound toxicity against doxorubicin resistant Brca1-/-;p53-/- spontaneous mouse mammary carcinoma cells. NSC57969 eradicates P-glycoprotein expression in doxorubicin resistant brca1-/-;p53-/- spontaneous mouse mammary carcinoma, and MES-SA/Dx5 cells. However treatment of normal cells (hCMEC/D3 cells) with NSC57969 does not induce loss of Pgp.

References

[1] András Füredi, et al. Identification and Validation of Compounds Selectively Killing Resistant Cancer: Delineating Cell Line-Specific Effects from P-Glycoprotein-Induced Toxicity. Mol Cancer Ther. 2017 Jan;16(1):45-56. DOI:10.1158/1535-7163.MCT-16-0333-T

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