BOC-D-TYR(ME)-OH Chemical Properties

Melting point:

93.0 to 97.0 °C

Boiling point:

462.0±40.0 °C(Predicted)

Density 

1.168±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,2-8°C

pka

3.00±0.10(Predicted)

form 

powder to crystal

color 

White to Almost white

optical activity

Consistent with structure

Safety Information

HazardClass 

IRRITANT

HS Code 

2924297099

BOC-D-TYR(ME)-OH Usage And Synthesis

Chemical Properties

White powder

Uses

Boc-O-methyl-D-tyrosine is a compound involved in the design and synthesis of β-sheet-based self-assembling cyclic peptides with tunable cavities.

Synthesis

General procedure for the synthesis of N-Boc-4-methoxy-D-phenylalanine from methyl (S)-2-((tert-butoxycarbonyl)amino)-3-(4-methoxyphenyl)propionate: in the presence of 1 mL of water, K2CO3 (0.089 g, 0.608 mmol) was added to a (S)-2-((tert-butoxycarbonyl)amino)-3-(4-methoxyphenyl) Methyl propionate (0.100 g, 0.323 mmol) was added to a solution in methanol (4 mL). The reaction mixture was stirred at room temperature for 12 hours. After completion of the reaction, methanol was removed by rotary evaporation. The reaction mixture was diluted with water and the aqueous layer was extracted with ethyl acetate. The organic layers were combined, dried with anhydrous Na2SO4, filtered and concentrated under reduced pressure. The crude product was purified by column chromatography using ethyl acetate and petroleum ether (1:1) as eluent to give pure N-Boc-4-methoxy-D-phenylalanine.

References

[1] Tetrahedron Letters, 2012, vol. 53, # 52, p. 7128 - 7130
[2] Journal of Organic Chemistry, 1981, vol. 46, # 9, p. 1944 - 1946
[3] Bioorganic and Medicinal Chemistry Letters, 2010, vol. 20, # 19, p. 5607 - 5612

BOC-D-TYR(ME)-OH(68856-96-2)Related Product Information

• BOC-D-TYR(ET)-OH
• BOC-D-TYR(BZL)-OH
• N-tert-Butyloxycarbonyl-O-(2-bromobenzyloxycarbonyl)-D-tyrosine
• Boc-Tyr(Me)-OH
• BOC-L-TYR(BZL)-OH
• Boc-L-Tyr(tBu)-OH
• O-METHYL-D-TYROSINE
• Boc-D-Tyr-OH
• BOC-D-TYR(BZL)-OSU
• BOC-D-TYR(2,6-DI-CL-BZL)-OH
• BOC-D-TYR(ALL)-OH,BOC-D-TYR(AL)-OH
• BOC-D-TYR(BZL, 3-NO2)-OH
• BOC-D-3,4-DIMETHOXYPHENYLALANINE
• BOC-D-METYR(BZL)-OH CHA
• BOC-D-TYR(ME)-OH
• Boc-D-Tyr(tBu)-OH
• BOC-BETA-TYR(ME)-OH
• BOC-L-TYR(BOC)-OH