VALERENIC ACID Chemical Properties

Melting point:

134-139°C

Boiling point:

374.5±21.0 °C(Predicted)

Density 

1.06±0.1 g/cm3(Predicted)

storage temp. 

−20°C

solubility 

Chloroform (Slightly), Ethanol (Slightly),Methanol (Slightly)

pka

4.88±0.19(Predicted)

color 

White to Off-White

BRN 

3138020

LogP

5.188 (est)

CAS DataBase Reference

3569-10-6(CAS DataBase Reference)

Safety Information

WGK Germany 

3

RTECS 

UD3357700

F 

8-10

HS Code 

2916205000

MSDS

• Language:English Provider:SigmaAldrich

VALERENIC ACID Usage And Synthesis

Uses

Valerenic Acid, acts as a subtype-selective GABAA receptor agonist in neonatal rat brainstem preparations. It can be used for the synthesis of Valerena-4,7(11)-diene, a highly active sedative.

Definition

ChEBI: A monocarboxylic acid that is 2-methylprop-2-enoic acid which is substituted at position 3 by a 3,7-dimethyl-2,4,5,6,7,7a-hexahydro-1H-inden-4-yl group. A bicyclic sesquiterpenoid constituent of the essential oil of the Valerian plant.

Biological Activity

Positive allosteric modulator of GABA A receptors that displays preference for receptors containing β 2 or β 3 subunits. Directly activates the receptor and also blocks the channel at high concentrations. Displays a sedative and anxiolytic activity in vivo . Also acts as a partial? agonist of 5-HT 5A receptors.

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