VALERENIC ACID
VALERENIC ACID Basic information
- Product Name:
- VALERENIC ACID
- Synonyms:
-
- VALERENIC ACID
- VALERENIC ACID WITH HPLC
- (E)-3-[(4S)-2,4,5,6,7,7aα-Hexahydro-3,7β-dimethyl-1H-inden-4-yl]-2-methylpropenoic acid
- (2E)-3-[(4S,7R,7aR)-2,4,5,6,7,7a-Hexadydro-3,7-dimethyl-1H-inden-4-yl]-2-methyl-2-propenoic acid
- 2-Propenoic acid, 3-(2,4,5,6,7,7A-hexahydro-3,7-dimethyl-1H-inden-4-yl)-2-methyl-, (4S-(4alpha(E),7beta,7aalpha))-
- Valerenic Acid (15 mg)
- VALERENIC ACID(P)
- VALERENIC ACID SNAP-N-SHOOT 0.1mg/mL(P)
- CAS:
- 3569-10-6
- MF:
- C15H22O2
- MW:
- 234.33
- EINECS:
- 203-677-2
- Product Categories:
-
- Plant Oils, Toxins, Phenolic Acids & Derivatives
- Natural Plant Extract
- Organic AcidsAnalytical Standards
- Alphabetic
- Chromatography
- Food&Beverage Standards
- V
- Mol File:
- 3569-10-6.mol
VALERENIC ACID Chemical Properties
- Melting point:
- 134-139°C
- Boiling point:
- 374.5±21.0 °C(Predicted)
- Density
- 1.06±0.1 g/cm3(Predicted)
- storage temp.
- −20°C
- solubility
- Chloroform (Slightly), Ethanol (Slightly),Methanol (Slightly)
- form
- Solid
- pka
- 4.88±0.19(Predicted)
- color
- White to Off-White
- BRN
- 3138020
- InChI
- InChI=1S/C15H22O2/c1-9-4-6-12(8-11(3)15(16)17)14-10(2)5-7-13(9)14/h8-9,12-13H,4-7H2,1-3H3,(H,16,17)/b11-8+/t9-,12+,13-/m1/s1
- InChIKey
- FEBNTWHYQKGEIQ-SUKRRCERSA-N
- SMILES
- C(O)(=O)/C(/C)=C/[C@@H]1CC[C@@H](C)[C@]2([H])C1=C(C)CC2
- LogP
- 5.188 (est)
- CAS DataBase Reference
- 3569-10-6(CAS DataBase Reference)
Safety Information
- WGK Germany
- 3
- RTECS
- UD3357700
- F
- 8-10
- HS Code
- 2916205000
MSDS
- Language:English Provider:SigmaAldrich
VALERENIC ACID Usage And Synthesis
Uses
Valerenic Acid, acts as a subtype-selective GABAA receptor agonist in neonatal rat brainstem preparations. It can be used for the synthesis of Valerena-4,7(11)-diene, a highly active sedative.
Definition
ChEBI: A monocarboxylic acid that is 2-methylprop-2-enoic acid which is substituted at position 3 by a 3,7-dimethyl-2,4,5,6,7,7a-hexahydro-1H-inden-4-yl group. A bicyclic sesquiterpenoid constituent of the essential oil of the Valerian plant.
Biological Activity
Positive allosteric modulator of GABA A receptors that displays preference for receptors containing β 2 or β 3 subunits. Directly activates the receptor and also blocks the channel at high concentrations. Displays a sedative and anxiolytic activity in vivo . Also acts as a partial? agonist of 5-HT 5A receptors.
in vivo
Valerenic acid (1-6 mg/kg i.p. or 10 mg/kg p.o.) decreases the aversion of wild type mice to the lit area[2].
Valerenic acid (10 mg/kg; p.o.) increases the proportion of time 129X1/SvJ mice spent onto the open arms[2].
IC 50
GABAA; 5-HT5A Receptor: 17.2 μM (IC50)
VALERENIC ACID Preparation Products And Raw materials
Preparation Products
VALERENIC ACIDSupplier
- Tel
- 028-028-85370565-229-229 18080489829
- 18080489829@163.com
- Tel
- 18210857532; 18210857532
- jkinfo@jkchemical.com
- Tel
- 4006356688 18621169109
- market03@meryer.com
- Tel
- 821-50328103-801 18930552037
- 3bsc@sina.com
- Tel
- 400-1166-196 18981987031
- cdhxsj@163.com
VALERENIC ACID(3569-10-6)Related Product Information
- Elderberry
- Cornmint oil
- VALERENIC ACID USP(CRM STANDARD)
- VALERENIC ACID SNAP-N-SHOOT 0.1MG/ML(SECONDARY STANDARD)
- VALERENIC ACID(AMERICAN HERBAL PHARMACOPOEIA)
- VALERIAN ROOT EXTRACT / VALERENIC ACID
- Didrovaltratum
- (2E)-3-CYCLOHEXYLPROP-2-ENOIC ACID
- VALENERAL
- ACETOXYVALERENIC ACID
- 2,4-DIMETHYL-2-PENTENOIC ACID
- 1-ETHYL-2-METHYLCYCLOPENTENE
- 1-BUTYLCYCLOPENTENE
- VALERENIC ACID
- 1-ISO-PROPYLCYCLOPENTENE
- 1,2,3-TRIMETHYLCYCLOPENTENE