1,2-DIOLEOYL-SN-GLYCEROL Chemical Properties

Boiling point:

670.8±35.0 °C(Predicted)

Density 

0.9218 g/cm3

storage temp. 

-20°C

solubility 

DMF: >20 mg/ml; DMSO: >7 mg/ml; Ethanol: >30 mg/ml; PBS pH 7.2: >250 μg/ml

pka

13.69±0.10(Predicted)

BRN 

1730457

Safety Information

Safety Statements 

22-24/25

WGK Germany 

3

RTECS 

RK1250000

F 

23

MSDS

• Language:English Provider:SigmaAldrich

1,2-DIOLEOYL-SN-GLYCEROL Usage And Synthesis

Description

1,2-Dioleoyl-sn-glycerol is an analog of the protein kinase C-activating second messenger DAG. 1,2-Dioleoyl-sn-glycerol and 1,2-dioctanoyl-sn-glycerol are nearly equipotent in induction of the acrosome reaction in human sperm.

Uses

1,2-Dioleoyl-sn-glycerol is an analog of 1,3-Dioleoylglycerol (D4842100 which is used in the synthesis of amphiphilic gadolinium complexes as MRI contrast agents.

Uses

18:1 DG may be used:

• in the lipid-protein overlay screen assay with Arabidopsis Rho-like GTPases recombinant protein and Arabidopsis plasma membrane H+-ATPase
• in the preparation of the Golgi-like liposomes
• in giant unilamellar vesicles (GUVs) preparation

Definition

ChEBI: A 1,2-diacyl-sn-glycerol in which the acyl groups at positions 1 and 2 are specified as oleoyl.

General Description

Diacylglycerol/diglyceride (DAG) is a glycerolipid, that is located at the plasma membrane. It is made up of two fatty acid chains that are covalently attached to a single glycerol molecule with the help of an ester linkage.

Biochem/physiol Actions

18:1 DG or 1,2-dioleoyl-sn-glycerol (DOG) fails to prevent the late fission events in the Golgi membrane. DOG is used in ferrihaem π–π tetramer aggregate preparation and β-haematin production.

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