5-NITRO-2-FUROYL CHLORIDE Chemical Properties

Melting point:

34-41 °C

Boiling point:

137-140°C 15mm

Density 

1.588±0.06 g/cm3(Predicted)

Flash point:

137-140°C/15mm

Sensitive 

Moisture Sensitive

BRN 

139693

CAS DataBase Reference

25084-14-4(CAS DataBase Reference)

Safety Information

Hazard Codes 

C

Risk Statements 

34

Safety Statements 

26-36/37/39-45

RIDADR 

3261

WGK Germany 

3

Hazard Note 

Corrosive

HazardClass 

8

PackingGroup 

II

HS Code 

2932190090

MSDS

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5-NITRO-2-FUROYL CHLORIDE Usage And Synthesis

Description

5-Nitrofuroyl chloride is a furan chain bound to an acyl and a nitro group. Nitrofuran derivatives have been used as antibiotic and antimicrobial drugs but the acyl group bound to furan (furoyl chloride) is an intermediate for the synthesis of pharmaceuticals (e.g. antibiotics). 5-Nitrofuroyl chloride has been used as a reagent for the synthesis of some compounds with antibacterial properties and other chemicals.

Uses

5-Nitrofuroyl chloride has been used in the synthesis of certain ureides of furanmonocarboxylic acid and in the synthesis of two salts of the mesoionic compound with an influence on the effectiveness of norfloxacin, tetracycline, and erythromycin. There is a study on the antibacterial effects of some 5-nirtofuroyl derivatives but not on 5-nitrofuroyl chloride. There are no reports on its commercial use.

Uses

5-Nitro-2-furoyl Chloride is used as reactant in the synthesis of several therapeutic agents.

Environmental Fate

5-Nitrofuroyl chloride is a colorless crystal with molecular weight of 175.53 g mol^-1. It is stable under normal temperature and pressure on the basis of its melting point (38–14℃). There are no available data on its solubility in water. The bioaccumulation factor (BCF) for this compound is 4.29 at pH 7.4, which indicates low accumulation in aquatic organisms. The soil adsorption coefficient normalized to the content of organic carbon (Koc value) is 98.92 at pH 7.4, which indicates high mobility in soil.

5-NITRO-2-FUROYL CHLORIDE(25084-14-4)Related Product Information

• 5-Chloro-2-Nitroacetanilide
• 2-Furoyl chloride
• 5-NITRO-2-METHYLFURAN
• 2-NITROFURAN
• 5-Nitrofurfural
• 5-NITRO-2-FUROYL CHLORIDE
• 2-Chloromethylfuran
• 2-(chloromethyl)-5-nitro-furan
• (2-METHYL-PYRIDIN-3-YL)-METHANOL
• furoyl chloride