RRM1 ANTIBODY Usage And Synthesis

Source

Rabbit

Reactivity

Human;Mouse;Monkey

Background

Ribonucleotide reductase catalyzes the rate-limiting step in the synthesis of deoxynucleotide triphosphates. The regulatory M1 subunit is present throughout the cell division cycle, but downregulated in quiescent cells. Research studies have demonstrated that RRM1 is involved in carcinogenesis and tumor progression, and its expression is correlated with resistance to chemotherapy in non-small cell lung cancer.

References

[1] Mann, G.J. et al. (1988) Cancer Res 48, 5151-6.
[2] Zheng, Z. et al. (2007) N Engl J Med 356, 800-8.
[3] Ceppi, P. et al. (2006) Ann Oncol 17, 1818-25.
[4] Bepler, G. et al. (2006) J Clin Oncol 24, 4731-7.

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