ATG5 ANTIBODY Usage And Synthesis

Source

Rabbit

Reactivity

Human;Monkey

Background

Autophagy is a catabolic process for the autophagosomic-lysosomal degradation of bulk cytoplasmic contents. Autophagy is generally activated by conditions of nutrient deprivation but has also been associated with a number of physiological processes including development, differentiation, neurodegeneration, infection, and cancer. The molecular machinery of autophagy was largely discovered in yeast and referred to as autophagy-related genes. Formation of the autophagosome involves a ubiquitin-like conjugation system in which Atg12 is covalently bound to Atg5 and targeted to autophagosome vesicles. This conjugation reaction is mediated by the ubiquitin E1-like enzyme Atg7 and the E2-like enzyme Atg10.

References

[1] Reggiori, F. and Klionsky, D.J. (2002) Eukaryot Cell 1, 11-21.
[2] Codogno, P. and Meijer, A.J. (2005) Cell Death Differ 12 Suppl 2, 1509-18.
[3] Levine, B. and Yuan, J. (2005) J Clin Invest 115, 2679-88.
[4] Mizushima, N. et al. (1998) J Biol Chem 273, 33889-92.
[5] Mizushima, N. et al. (1998) Nature 395, 395-8.
[6] Suzuki, K. et al. (2001) EMBO J 20, 5971-81.
[7] Tanida, I. et al. (1999) Mol Biol Cell 10, 1367-79.
[8] Shintani, T. et al. (1999) EMBO J 18, 5234-41.

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