CRTH2-IN-1 Chemical Properties

Boiling point:

636.5±65.0 °C(Predicted)

Density 

1.41±0.1 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

Soluble in DMSO

pka

4.50±0.10(Predicted)

CRTH2-IN-1 Usage And Synthesis

Uses

CRTH2-IN-1 (Ramatroban analog) is a selective prostaglandin D2 receptor DP2 (CRTH2) antagonist with an IC50 of 6 nM in a human DP2 binding assay.

IC 50

CYP 2C9: 5 μM (IC₅₀); CYP3A4: 7 μM (IC₅₀); hDP2: 6 nM (IC₅₀); hDP1: 1 μM (IC₅₀)

References

[1] Stearns BA, et al. Novel tricyclic antagonists of the prostaglandin D2 receptor DP2 with efficacy in a murine modelof allergic rhinitis. Bioorg Med Chem Lett. 2009 Aug 15;19(16):4647-51. DOI:10.1016/j.bmcl.2009.06.085