LOM612 Chemical Properties

Boiling point:

386.2±42.0 °C(Predicted)

Density 

1.436±0.06 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

DMSO : 6 mg/mL (23.23 mM);Water : < 0.1 mg/mL (insoluble)

form 

Solid

pka

3.04±0.20(Predicted)

color 

Pink to red

LOM612 Usage And Synthesis

Uses

LOM612 is a potent FOXO relocator, with an EC50 value of 1.5 μM in U2fox RELOC cells[1].

References

[1] Cautain B, et al. Discovery of a Novel, Isothiazolonaphthoquinone-Based Small Molecule Activator of FOXO Nuclear-Cytoplasmic Shuttling. PLoS One. 2016 Dec 9;11(12):e0167491. DOI:10.1371/journal.pone.0167491