10-(4-methoxybenzoyl)-10h-phenoxazine-3-carbonitrile Chemical Properties

Melting point:

184-185 °C

Boiling point:

550.8±50.0 °C(Predicted)

Density 

1.38±0.1 g/cm3(Predicted)

pka

-6.73±0.20(Predicted)

10-(4-methoxybenzoyl)-10h-phenoxazine-3-carbonitrile Usage And Synthesis

Uses

Tubulin inhibitor 8 (Compound 33b) is a tubulin inhibitor and a potent inhibitor of multiple cancer cell lines. Tubulin inhibitor 8 inhibits tubulin polymerization with an IC50 of 0.73 μM. Tubulin inhibitor 8 inhibits K562 cell growth with an IC50 of 14 nM[1].

References

[1] Prinz H, et al. N-benzoylated phenoxazines and phenothiazines: synthesis, antiproliferative activity, and inhibition of tubulin polymerization. J Med Chem. 2011 Jun 23;54(12):4247-63. DOI:10.1021/jm200436t