AZD7507
AZD7507 Basic information
- Product Name:
- AZD7507
- Synonyms:
-
- AZD7507
- AZD7507; AZD-7507; AZD 7507;1041852-85-0
- CS-2850
- 4-(2-fluoro-4-methylanilino)-6-[4-(2-hydroxyethyl)piperazin-1-yl]-7-methoxycinnoline-3-carboxamide
- 3-Cinnolinecarboxamide, 4-[(2-fluoro-4-methylphenyl)amino]-6-[4-(2-hydroxyethyl)-1-piperazinyl]-7-methoxy-
- AZD7507,AZD 7507,Inhibitor,AZD-7507,CSF-1R,CSF1R,CSF-1 receptor,c-Fms,inhibit,colony stimulating factor 1 receptor
- AZD7507, 10 mM in DMSO
- CAS:
- 1041852-85-0
- MF:
- C23H27FN6O3
- MW:
- 454.5
- Mol File:
- 1041852-85-0.mol
AZD7507 Chemical Properties
- Boiling point:
- 680.7±65.0 °C(Predicted)
- Density
- 1.346±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- form
- Solid
- pka
- 14.47±0.30(Predicted)
- color
- Light yellow to yellow
AZD7507 Usage And Synthesis
Uses
AZD7507 is a potent and orally active CSF-1R inhibitor, with antitumor activity.
in vivo
AZD7507 has good rat oral PK, with in vivo clearance of 7 mL/min/kg and 42% bioavailability. In the canine L-type Ca channel assay, the IC50 is >20 μM[1]. AZD7507 significantly decreases the number of CD68+ macrophages in mice, and also reduces the volume and mass in mice bearing CC-LP-1 and SNU-1079 cells, but not WITT-1 cells[2].
References
[1] Scott DA, et al. Mitigation of cardiovascular toxicity in a series of CSF-1R inhibitors, and the identification of AZD7507. Bioorg Med Chem Lett. 2013 Aug 15;23(16):4591-6. DOI:10.1016/j.bmcl.2013.06.031
[2] Boulter L, et al. WNT signaling drives cholangiocarcinoma growth and can be pharmacologically inhibited. Send to J Clin Invest. 2015 Mar 2;125(3):1269-85. DOI:10.1172/JCI76452
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